Transition into and out of a focal seizure

Research output: Chapter in Book/Report/Conference proceedingChapter


It is commonly assumed that seizure activity correlates with enhanced neuronal synchronization and increased excitation. Increasing evidence, based on both intracranial recordings in humans and data obtained in animal models, suggests that synchronization of inhibition is required to initiate a focal seizure and that synchronization among principal cells decreases at seizure onset and gradually recovers during late ictal phases. These findings are here reviewed and are discussed in the context of focal ictogenesis.

Original languageEnglish
Title of host publicationRecent Advance in Predicting and Preventing Epileptic Sezures
PublisherWorld Scientific Publishing Co.
Number of pages13
ISBN (Print)9789814525350, 9789814525343
Publication statusPublished - Jan 1 2013


  • Ictal discharges
  • Ictogenesis
  • Interictal events
  • Synchronization

ASJC Scopus subject areas

  • Computer Science(all)
  • Medicine(all)
  • Neuroscience(all)


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