Transition phase towards psoriatic arthritis: Clinical and ultrasonographic characterisation of psoriatic arthralgia

Alen Zabotti, Dennis G. McGonagle, Ivan Giovannini, Enzo Errichetti, Francesca Zuliani, Anna Zanetti, Ilaria Tinazzi, Orazio De Lucia, Alberto Batticciotto, Luca Idolazzi, Garifallia Sakellariou, Sara Zandonella Callegher, Stefania Sacco, Luca Quartuccio, Annamaria Iagnocco, Salvatore De Vita

Research output: Contribution to journalArticle

Abstract

Objective Non-specific musculoskeletal pain is common in subjects destined to develop psoriatic arthritis (PsA). We evaluated psoriatic patients with arthralgia (PsOAr) compared with psoriasis alone (PsO) and healthy controls (HCs) using ultrasonography (US) to investigate the anatomical basis for joint symptoms in PsOAr and the link between these imaging findings and subsequent PsA transition. Methods A cross-sectional prevalence analysis of clinical and US abnormalities (including inflammatory and structural lesions) in PsOAr (n=61), PsO (n=57) and HCs (n=57) was performed, with subsequent prospective follow-up for PsA development. Results Tenosynovitis was the only significant sonographic feature that differed between PsOAr and PsO (29.5% vs 5.3%, p<0.001), although synovitis and enthesitis were numerically more frequent in PsOAr. Five patients in PsOAr and one in PsO group developed PsA, with an incidence rate of 109.2/1000 person-years in PsOAr vs 13.4/1000 person-years in PsO (p=0.03). Visual Analogue Scale pain, Health Assessment Questionnaire, joint tenderness and US active enthesitis were baseline variables associated with PsA development. Conclusion Tenosynovitis was associated with arthralgia in subjects with psoriasis. Baseline US evidence of enthesitis was associated with clinical PsA development in the longitudinal analysis. These findings are relevant for enriching for subjects at risk of imminent PsA development.

Original languageEnglish
Article numbere001067
JournalRMD Open
Volume5
Issue number2
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Psoriatic Arthritis
Phase Transition
Arthralgia
Psoriasis
Ultrasonography
Tenosynovitis
Joints
Musculoskeletal Pain
Synovitis
Pain Measurement
Visual Analog Scale
Cross-Sectional Studies
Incidence
Health

Keywords

  • pain
  • preclinical phase
  • psoriasis
  • psoriatic arthralgia
  • psoriatic arthritis
  • ultrasound

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology

Cite this

Zabotti, A., McGonagle, D. G., Giovannini, I., Errichetti, E., Zuliani, F., Zanetti, A., ... De Vita, S. (2019). Transition phase towards psoriatic arthritis: Clinical and ultrasonographic characterisation of psoriatic arthralgia. RMD Open, 5(2), [e001067]. https://doi.org/10.1136/rmdopen-2019-001067

Transition phase towards psoriatic arthritis : Clinical and ultrasonographic characterisation of psoriatic arthralgia. / Zabotti, Alen; McGonagle, Dennis G.; Giovannini, Ivan; Errichetti, Enzo; Zuliani, Francesca; Zanetti, Anna; Tinazzi, Ilaria; De Lucia, Orazio; Batticciotto, Alberto; Idolazzi, Luca; Sakellariou, Garifallia; Zandonella Callegher, Sara; Sacco, Stefania; Quartuccio, Luca; Iagnocco, Annamaria; De Vita, Salvatore.

In: RMD Open, Vol. 5, No. 2, e001067, 01.01.2019.

Research output: Contribution to journalArticle

Zabotti, A, McGonagle, DG, Giovannini, I, Errichetti, E, Zuliani, F, Zanetti, A, Tinazzi, I, De Lucia, O, Batticciotto, A, Idolazzi, L, Sakellariou, G, Zandonella Callegher, S, Sacco, S, Quartuccio, L, Iagnocco, A & De Vita, S 2019, 'Transition phase towards psoriatic arthritis: Clinical and ultrasonographic characterisation of psoriatic arthralgia', RMD Open, vol. 5, no. 2, e001067. https://doi.org/10.1136/rmdopen-2019-001067
Zabotti, Alen ; McGonagle, Dennis G. ; Giovannini, Ivan ; Errichetti, Enzo ; Zuliani, Francesca ; Zanetti, Anna ; Tinazzi, Ilaria ; De Lucia, Orazio ; Batticciotto, Alberto ; Idolazzi, Luca ; Sakellariou, Garifallia ; Zandonella Callegher, Sara ; Sacco, Stefania ; Quartuccio, Luca ; Iagnocco, Annamaria ; De Vita, Salvatore. / Transition phase towards psoriatic arthritis : Clinical and ultrasonographic characterisation of psoriatic arthralgia. In: RMD Open. 2019 ; Vol. 5, No. 2.
@article{7da7046b3e684491b590bd2a2bc6d268,
title = "Transition phase towards psoriatic arthritis: Clinical and ultrasonographic characterisation of psoriatic arthralgia",
abstract = "Objective Non-specific musculoskeletal pain is common in subjects destined to develop psoriatic arthritis (PsA). We evaluated psoriatic patients with arthralgia (PsOAr) compared with psoriasis alone (PsO) and healthy controls (HCs) using ultrasonography (US) to investigate the anatomical basis for joint symptoms in PsOAr and the link between these imaging findings and subsequent PsA transition. Methods A cross-sectional prevalence analysis of clinical and US abnormalities (including inflammatory and structural lesions) in PsOAr (n=61), PsO (n=57) and HCs (n=57) was performed, with subsequent prospective follow-up for PsA development. Results Tenosynovitis was the only significant sonographic feature that differed between PsOAr and PsO (29.5{\%} vs 5.3{\%}, p<0.001), although synovitis and enthesitis were numerically more frequent in PsOAr. Five patients in PsOAr and one in PsO group developed PsA, with an incidence rate of 109.2/1000 person-years in PsOAr vs 13.4/1000 person-years in PsO (p=0.03). Visual Analogue Scale pain, Health Assessment Questionnaire, joint tenderness and US active enthesitis were baseline variables associated with PsA development. Conclusion Tenosynovitis was associated with arthralgia in subjects with psoriasis. Baseline US evidence of enthesitis was associated with clinical PsA development in the longitudinal analysis. These findings are relevant for enriching for subjects at risk of imminent PsA development.",
keywords = "pain, preclinical phase, psoriasis, psoriatic arthralgia, psoriatic arthritis, ultrasound",
author = "Alen Zabotti and McGonagle, {Dennis G.} and Ivan Giovannini and Enzo Errichetti and Francesca Zuliani and Anna Zanetti and Ilaria Tinazzi and {De Lucia}, Orazio and Alberto Batticciotto and Luca Idolazzi and Garifallia Sakellariou and {Zandonella Callegher}, Sara and Stefania Sacco and Luca Quartuccio and Annamaria Iagnocco and {De Vita}, Salvatore",
year = "2019",
month = "1",
day = "1",
doi = "10.1136/rmdopen-2019-001067",
language = "English",
volume = "5",
journal = "RMD Open",
issn = "2056-5933",
publisher = "BMJ Publishing Group",
number = "2",

}

TY - JOUR

T1 - Transition phase towards psoriatic arthritis

T2 - Clinical and ultrasonographic characterisation of psoriatic arthralgia

AU - Zabotti, Alen

AU - McGonagle, Dennis G.

AU - Giovannini, Ivan

AU - Errichetti, Enzo

AU - Zuliani, Francesca

AU - Zanetti, Anna

AU - Tinazzi, Ilaria

AU - De Lucia, Orazio

AU - Batticciotto, Alberto

AU - Idolazzi, Luca

AU - Sakellariou, Garifallia

AU - Zandonella Callegher, Sara

AU - Sacco, Stefania

AU - Quartuccio, Luca

AU - Iagnocco, Annamaria

AU - De Vita, Salvatore

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objective Non-specific musculoskeletal pain is common in subjects destined to develop psoriatic arthritis (PsA). We evaluated psoriatic patients with arthralgia (PsOAr) compared with psoriasis alone (PsO) and healthy controls (HCs) using ultrasonography (US) to investigate the anatomical basis for joint symptoms in PsOAr and the link between these imaging findings and subsequent PsA transition. Methods A cross-sectional prevalence analysis of clinical and US abnormalities (including inflammatory and structural lesions) in PsOAr (n=61), PsO (n=57) and HCs (n=57) was performed, with subsequent prospective follow-up for PsA development. Results Tenosynovitis was the only significant sonographic feature that differed between PsOAr and PsO (29.5% vs 5.3%, p<0.001), although synovitis and enthesitis were numerically more frequent in PsOAr. Five patients in PsOAr and one in PsO group developed PsA, with an incidence rate of 109.2/1000 person-years in PsOAr vs 13.4/1000 person-years in PsO (p=0.03). Visual Analogue Scale pain, Health Assessment Questionnaire, joint tenderness and US active enthesitis were baseline variables associated with PsA development. Conclusion Tenosynovitis was associated with arthralgia in subjects with psoriasis. Baseline US evidence of enthesitis was associated with clinical PsA development in the longitudinal analysis. These findings are relevant for enriching for subjects at risk of imminent PsA development.

AB - Objective Non-specific musculoskeletal pain is common in subjects destined to develop psoriatic arthritis (PsA). We evaluated psoriatic patients with arthralgia (PsOAr) compared with psoriasis alone (PsO) and healthy controls (HCs) using ultrasonography (US) to investigate the anatomical basis for joint symptoms in PsOAr and the link between these imaging findings and subsequent PsA transition. Methods A cross-sectional prevalence analysis of clinical and US abnormalities (including inflammatory and structural lesions) in PsOAr (n=61), PsO (n=57) and HCs (n=57) was performed, with subsequent prospective follow-up for PsA development. Results Tenosynovitis was the only significant sonographic feature that differed between PsOAr and PsO (29.5% vs 5.3%, p<0.001), although synovitis and enthesitis were numerically more frequent in PsOAr. Five patients in PsOAr and one in PsO group developed PsA, with an incidence rate of 109.2/1000 person-years in PsOAr vs 13.4/1000 person-years in PsO (p=0.03). Visual Analogue Scale pain, Health Assessment Questionnaire, joint tenderness and US active enthesitis were baseline variables associated with PsA development. Conclusion Tenosynovitis was associated with arthralgia in subjects with psoriasis. Baseline US evidence of enthesitis was associated with clinical PsA development in the longitudinal analysis. These findings are relevant for enriching for subjects at risk of imminent PsA development.

KW - pain

KW - preclinical phase

KW - psoriasis

KW - psoriatic arthralgia

KW - psoriatic arthritis

KW - ultrasound

UR - http://www.scopus.com/inward/record.url?scp=85074423417&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85074423417&partnerID=8YFLogxK

U2 - 10.1136/rmdopen-2019-001067

DO - 10.1136/rmdopen-2019-001067

M3 - Article

AN - SCOPUS:85074423417

VL - 5

JO - RMD Open

JF - RMD Open

SN - 2056-5933

IS - 2

M1 - e001067

ER -