Transitional cell carcinoma of the bladder in children and adolescents: Six-case series and review of the literature

Javier Lerena, Lucas Krauel, Luis García-Aparicio, Santiago Vallasciani, Mariona Suñol, Joan Rodó

Research output: Contribution to journalArticle

Abstract

Objective: Lower urinary tract tumours are uncommon in paediatrics. Transitional cell carcinoma of the bladder (TCCB) is rarely found in the first two decades of life and is exceptional under 10 years of age. The present series aimed to expand the number of reported cases in the literature. Patients and methods: In 1984-2007, six patients (four male, two female), aged 6, 9, 12, 13, 14 and 17 years, were treated at our centre. Clinical presentation was macroscopic haematuria in five and pyelonephritis in one. Physical examination, laboratory analysis, ultrasound and cystoscopy were performed before surgical treatment in all patients. Follow up was by clinical and ultrasound assessment. Results: Neither physical examination nor laboratory analysis revealed any significant abnormalities, but ultrasound showed exophytic intravesical lesions. Surgical resection was performed endoscopically. Histological studies showed grade I TCCB in all cases. The immediate postoperative period was uneventful and long-term follow up did not reveal recurrence. Conclusion: Despite its low incidence in children, TCCB must be suspected in the event of macroscopic haematuria. Ultrasound followed by cystoscopy are the ideal diagnostic tools for visualization of these tumours. Endoscopic resection proved effective in all the present cases. Follow up must be clinical with periodic ultrasound evaluation. Urine cytologic examination is ineffective. Periodic cystoscopy is indicated only in cases of clinical or ultrasonographic suspicion of recurrence.

Original languageEnglish
Pages (from-to)481-485
Number of pages5
JournalJournal of Pediatric Urology
Volume6
Issue number5
DOIs
Publication statusPublished - Oct 2010

Fingerprint

Cystoscopy
Transitional Cell Carcinoma
Urinary Bladder
Hematuria
Physical Examination
Recurrence
Pyelonephritis
Urinary Tract
Postoperative Period
Neoplasms
Urine
Pediatrics
Incidence
Therapeutics

Keywords

  • Bladder
  • Children
  • Transitional cell carcinoma
  • Treatment

ASJC Scopus subject areas

  • Urology
  • Pediatrics, Perinatology, and Child Health

Cite this

Transitional cell carcinoma of the bladder in children and adolescents : Six-case series and review of the literature. / Lerena, Javier; Krauel, Lucas; García-Aparicio, Luis; Vallasciani, Santiago; Suñol, Mariona; Rodó, Joan.

In: Journal of Pediatric Urology, Vol. 6, No. 5, 10.2010, p. 481-485.

Research output: Contribution to journalArticle

Lerena, Javier ; Krauel, Lucas ; García-Aparicio, Luis ; Vallasciani, Santiago ; Suñol, Mariona ; Rodó, Joan. / Transitional cell carcinoma of the bladder in children and adolescents : Six-case series and review of the literature. In: Journal of Pediatric Urology. 2010 ; Vol. 6, No. 5. pp. 481-485.
@article{124c308939d8490da8b314414fd9d29c,
title = "Transitional cell carcinoma of the bladder in children and adolescents: Six-case series and review of the literature",
abstract = "Objective: Lower urinary tract tumours are uncommon in paediatrics. Transitional cell carcinoma of the bladder (TCCB) is rarely found in the first two decades of life and is exceptional under 10 years of age. The present series aimed to expand the number of reported cases in the literature. Patients and methods: In 1984-2007, six patients (four male, two female), aged 6, 9, 12, 13, 14 and 17 years, were treated at our centre. Clinical presentation was macroscopic haematuria in five and pyelonephritis in one. Physical examination, laboratory analysis, ultrasound and cystoscopy were performed before surgical treatment in all patients. Follow up was by clinical and ultrasound assessment. Results: Neither physical examination nor laboratory analysis revealed any significant abnormalities, but ultrasound showed exophytic intravesical lesions. Surgical resection was performed endoscopically. Histological studies showed grade I TCCB in all cases. The immediate postoperative period was uneventful and long-term follow up did not reveal recurrence. Conclusion: Despite its low incidence in children, TCCB must be suspected in the event of macroscopic haematuria. Ultrasound followed by cystoscopy are the ideal diagnostic tools for visualization of these tumours. Endoscopic resection proved effective in all the present cases. Follow up must be clinical with periodic ultrasound evaluation. Urine cytologic examination is ineffective. Periodic cystoscopy is indicated only in cases of clinical or ultrasonographic suspicion of recurrence.",
keywords = "Bladder, Children, Transitional cell carcinoma, Treatment",
author = "Javier Lerena and Lucas Krauel and Luis Garc{\'i}a-Aparicio and Santiago Vallasciani and Mariona Su{\~n}ol and Joan Rod{\'o}",
year = "2010",
month = "10",
doi = "10.1016/j.jpurol.2009.11.006",
language = "English",
volume = "6",
pages = "481--485",
journal = "Journal of Pediatric Urology",
issn = "1477-5131",
publisher = "Elsevier BV",
number = "5",

}

TY - JOUR

T1 - Transitional cell carcinoma of the bladder in children and adolescents

T2 - Six-case series and review of the literature

AU - Lerena, Javier

AU - Krauel, Lucas

AU - García-Aparicio, Luis

AU - Vallasciani, Santiago

AU - Suñol, Mariona

AU - Rodó, Joan

PY - 2010/10

Y1 - 2010/10

N2 - Objective: Lower urinary tract tumours are uncommon in paediatrics. Transitional cell carcinoma of the bladder (TCCB) is rarely found in the first two decades of life and is exceptional under 10 years of age. The present series aimed to expand the number of reported cases in the literature. Patients and methods: In 1984-2007, six patients (four male, two female), aged 6, 9, 12, 13, 14 and 17 years, were treated at our centre. Clinical presentation was macroscopic haematuria in five and pyelonephritis in one. Physical examination, laboratory analysis, ultrasound and cystoscopy were performed before surgical treatment in all patients. Follow up was by clinical and ultrasound assessment. Results: Neither physical examination nor laboratory analysis revealed any significant abnormalities, but ultrasound showed exophytic intravesical lesions. Surgical resection was performed endoscopically. Histological studies showed grade I TCCB in all cases. The immediate postoperative period was uneventful and long-term follow up did not reveal recurrence. Conclusion: Despite its low incidence in children, TCCB must be suspected in the event of macroscopic haematuria. Ultrasound followed by cystoscopy are the ideal diagnostic tools for visualization of these tumours. Endoscopic resection proved effective in all the present cases. Follow up must be clinical with periodic ultrasound evaluation. Urine cytologic examination is ineffective. Periodic cystoscopy is indicated only in cases of clinical or ultrasonographic suspicion of recurrence.

AB - Objective: Lower urinary tract tumours are uncommon in paediatrics. Transitional cell carcinoma of the bladder (TCCB) is rarely found in the first two decades of life and is exceptional under 10 years of age. The present series aimed to expand the number of reported cases in the literature. Patients and methods: In 1984-2007, six patients (four male, two female), aged 6, 9, 12, 13, 14 and 17 years, were treated at our centre. Clinical presentation was macroscopic haematuria in five and pyelonephritis in one. Physical examination, laboratory analysis, ultrasound and cystoscopy were performed before surgical treatment in all patients. Follow up was by clinical and ultrasound assessment. Results: Neither physical examination nor laboratory analysis revealed any significant abnormalities, but ultrasound showed exophytic intravesical lesions. Surgical resection was performed endoscopically. Histological studies showed grade I TCCB in all cases. The immediate postoperative period was uneventful and long-term follow up did not reveal recurrence. Conclusion: Despite its low incidence in children, TCCB must be suspected in the event of macroscopic haematuria. Ultrasound followed by cystoscopy are the ideal diagnostic tools for visualization of these tumours. Endoscopic resection proved effective in all the present cases. Follow up must be clinical with periodic ultrasound evaluation. Urine cytologic examination is ineffective. Periodic cystoscopy is indicated only in cases of clinical or ultrasonographic suspicion of recurrence.

KW - Bladder

KW - Children

KW - Transitional cell carcinoma

KW - Treatment

UR - http://www.scopus.com/inward/record.url?scp=77956620092&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956620092&partnerID=8YFLogxK

U2 - 10.1016/j.jpurol.2009.11.006

DO - 10.1016/j.jpurol.2009.11.006

M3 - Article

C2 - 20080447

AN - SCOPUS:77956620092

VL - 6

SP - 481

EP - 485

JO - Journal of Pediatric Urology

JF - Journal of Pediatric Urology

SN - 1477-5131

IS - 5

ER -