Abstract
Objective: Lower urinary tract tumours are uncommon in paediatrics. Transitional cell carcinoma of the bladder (TCCB) is rarely found in the first two decades of life and is exceptional under 10 years of age. The present series aimed to expand the number of reported cases in the literature. Patients and methods: In 1984-2007, six patients (four male, two female), aged 6, 9, 12, 13, 14 and 17 years, were treated at our centre. Clinical presentation was macroscopic haematuria in five and pyelonephritis in one. Physical examination, laboratory analysis, ultrasound and cystoscopy were performed before surgical treatment in all patients. Follow up was by clinical and ultrasound assessment. Results: Neither physical examination nor laboratory analysis revealed any significant abnormalities, but ultrasound showed exophytic intravesical lesions. Surgical resection was performed endoscopically. Histological studies showed grade I TCCB in all cases. The immediate postoperative period was uneventful and long-term follow up did not reveal recurrence. Conclusion: Despite its low incidence in children, TCCB must be suspected in the event of macroscopic haematuria. Ultrasound followed by cystoscopy are the ideal diagnostic tools for visualization of these tumours. Endoscopic resection proved effective in all the present cases. Follow up must be clinical with periodic ultrasound evaluation. Urine cytologic examination is ineffective. Periodic cystoscopy is indicated only in cases of clinical or ultrasonographic suspicion of recurrence.
| Original language | English |
|---|---|
| Pages (from-to) | 481-485 |
| Number of pages | 5 |
| Journal | Journal of Pediatric Urology |
| Volume | 6 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Oct 2010 |
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Keywords
- Bladder
- Children
- Transitional cell carcinoma
- Treatment
ASJC Scopus subject areas
- Urology
- Pediatrics, Perinatology, and Child Health
Cite this
Transitional cell carcinoma of the bladder in children and adolescents : Six-case series and review of the literature. / Lerena, Javier; Krauel, Lucas; García-Aparicio, Luis; Vallasciani, Santiago; Suñol, Mariona; Rodó, Joan.
In: Journal of Pediatric Urology, Vol. 6, No. 5, 10.2010, p. 481-485.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Transitional cell carcinoma of the bladder in children and adolescents
T2 - Six-case series and review of the literature
AU - Lerena, Javier
AU - Krauel, Lucas
AU - García-Aparicio, Luis
AU - Vallasciani, Santiago
AU - Suñol, Mariona
AU - Rodó, Joan
PY - 2010/10
Y1 - 2010/10
N2 - Objective: Lower urinary tract tumours are uncommon in paediatrics. Transitional cell carcinoma of the bladder (TCCB) is rarely found in the first two decades of life and is exceptional under 10 years of age. The present series aimed to expand the number of reported cases in the literature. Patients and methods: In 1984-2007, six patients (four male, two female), aged 6, 9, 12, 13, 14 and 17 years, were treated at our centre. Clinical presentation was macroscopic haematuria in five and pyelonephritis in one. Physical examination, laboratory analysis, ultrasound and cystoscopy were performed before surgical treatment in all patients. Follow up was by clinical and ultrasound assessment. Results: Neither physical examination nor laboratory analysis revealed any significant abnormalities, but ultrasound showed exophytic intravesical lesions. Surgical resection was performed endoscopically. Histological studies showed grade I TCCB in all cases. The immediate postoperative period was uneventful and long-term follow up did not reveal recurrence. Conclusion: Despite its low incidence in children, TCCB must be suspected in the event of macroscopic haematuria. Ultrasound followed by cystoscopy are the ideal diagnostic tools for visualization of these tumours. Endoscopic resection proved effective in all the present cases. Follow up must be clinical with periodic ultrasound evaluation. Urine cytologic examination is ineffective. Periodic cystoscopy is indicated only in cases of clinical or ultrasonographic suspicion of recurrence.
AB - Objective: Lower urinary tract tumours are uncommon in paediatrics. Transitional cell carcinoma of the bladder (TCCB) is rarely found in the first two decades of life and is exceptional under 10 years of age. The present series aimed to expand the number of reported cases in the literature. Patients and methods: In 1984-2007, six patients (four male, two female), aged 6, 9, 12, 13, 14 and 17 years, were treated at our centre. Clinical presentation was macroscopic haematuria in five and pyelonephritis in one. Physical examination, laboratory analysis, ultrasound and cystoscopy were performed before surgical treatment in all patients. Follow up was by clinical and ultrasound assessment. Results: Neither physical examination nor laboratory analysis revealed any significant abnormalities, but ultrasound showed exophytic intravesical lesions. Surgical resection was performed endoscopically. Histological studies showed grade I TCCB in all cases. The immediate postoperative period was uneventful and long-term follow up did not reveal recurrence. Conclusion: Despite its low incidence in children, TCCB must be suspected in the event of macroscopic haematuria. Ultrasound followed by cystoscopy are the ideal diagnostic tools for visualization of these tumours. Endoscopic resection proved effective in all the present cases. Follow up must be clinical with periodic ultrasound evaluation. Urine cytologic examination is ineffective. Periodic cystoscopy is indicated only in cases of clinical or ultrasonographic suspicion of recurrence.
KW - Bladder
KW - Children
KW - Transitional cell carcinoma
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=77956620092&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956620092&partnerID=8YFLogxK
U2 - 10.1016/j.jpurol.2009.11.006
DO - 10.1016/j.jpurol.2009.11.006
M3 - Article
C2 - 20080447
AN - SCOPUS:77956620092
VL - 6
SP - 481
EP - 485
JO - Journal of Pediatric Urology
JF - Journal of Pediatric Urology
SN - 1477-5131
IS - 5
ER -