Transitory expansion of a CD3+TcR γ/δ+CD16+ lymphocytic population in two patients with advanced human immunodeficiency virus infection and high levels of natural killer activity

G. Tambussi, V. Albarello, A. Gori, C. Bisson, A. Lazzarin

Research output: Contribution to journalArticlepeer-review

Abstract

In the present study, we describe an expansion of CD16+ cells with a CD3+ TcR γ/δ+ phenotype, in the presence of normal numbers of 'classic' CD3-CD16+ natural killer (NK) cells, in two patients with human immunodeficiency virus (HIV) infection in late stage. The NK activity of the two subjects was substantially higher then that of HIV+ subjects in the same stage of infection. A second evaluation of one of the patients showed levels of NK activity consistent with the clinical stage of HIV infection, concomitant with a remarkable reduction in the percentage of double-positive CD3/TcR γ/δ cells. The number of CD16+ cells also reached values comparable to those of the control group. In conclusion, we have identified a population of CD3+TcR γ/δ+CD16+ cells that have the capability to lyse an NK-sensitive target in two patients with unusually high levels of NK activity.

Original languageEnglish
Pages (from-to)711-715
Number of pages5
JournalAIDS Research and Human Retroviruses
Volume10
Issue number6
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Immunology
  • Virology

Fingerprint Dive into the research topics of 'Transitory expansion of a CD3+TcR γ/δ+CD16+ lymphocytic population in two patients with advanced human immunodeficiency virus infection and high levels of natural killer activity'. Together they form a unique fingerprint.

Cite this