TY - JOUR
T1 - Transjugular liver biopsy
T2 - How good is it for accurate histological interpretation?
AU - Cholongitas, E.
AU - Quaglia, A.
AU - Samonakis, D.
AU - Senzolo, M.
AU - Triantos, C.
AU - Patch, D.
AU - Leandro, G.
AU - Dhillon, A. P.
AU - Burroughs, A. K.
PY - 2006/12
Y1 - 2006/12
N2 - Background: A transjugular liver biopsy (TJLB) specimen is often smaller or more fragmented than a percutaneous liver biopsy (PLB) specimen. Recently, for PLB, the minimum requirements to evaluate chronic hepatitis have been set at 20-25 mm length and ≥11 complete portal tracts. Aim: To evaluate and compare length of TJLB and PLB specimens, portal tract number, fragmentation and adequacy for histopathological diagnosis and staging. Patients and methods: 326 consecutive TJLB specimens in 274 patients (109 who had undergone a transplantation), always using three passes (19-G Tru-cut) and 40 consecutive PLB specimens (15-G Menghini). Results: No technical failures occurred with the TJLB, and histological diagnosis was possible in 98.5%. The median (range) number of fragments was 5 (1-13) and the median total length was 22 (3-46) mm, with 65% of specimens ≥20 mm and 36% ≥25 mm; 60% of TJLB specimens were ≥28 mm long had ≥11 complete portal tracts. No difference in complete portal tract number or biopsy length was found between PLB and TJLB specimens. Conclusion: A TJLB specimen with three passes is adequate for histological diagnosis, with 89% of specimens being either ≥15 mm or having ≥6 complete portal tracts. Although adequate sampling remains a limitation for staging and grading of chronic hepatitis, TJLB is comparable to PLB in this respect.
AB - Background: A transjugular liver biopsy (TJLB) specimen is often smaller or more fragmented than a percutaneous liver biopsy (PLB) specimen. Recently, for PLB, the minimum requirements to evaluate chronic hepatitis have been set at 20-25 mm length and ≥11 complete portal tracts. Aim: To evaluate and compare length of TJLB and PLB specimens, portal tract number, fragmentation and adequacy for histopathological diagnosis and staging. Patients and methods: 326 consecutive TJLB specimens in 274 patients (109 who had undergone a transplantation), always using three passes (19-G Tru-cut) and 40 consecutive PLB specimens (15-G Menghini). Results: No technical failures occurred with the TJLB, and histological diagnosis was possible in 98.5%. The median (range) number of fragments was 5 (1-13) and the median total length was 22 (3-46) mm, with 65% of specimens ≥20 mm and 36% ≥25 mm; 60% of TJLB specimens were ≥28 mm long had ≥11 complete portal tracts. No difference in complete portal tract number or biopsy length was found between PLB and TJLB specimens. Conclusion: A TJLB specimen with three passes is adequate for histological diagnosis, with 89% of specimens being either ≥15 mm or having ≥6 complete portal tracts. Although adequate sampling remains a limitation for staging and grading of chronic hepatitis, TJLB is comparable to PLB in this respect.
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U2 - 10.1136/gut.2005.090415
DO - 10.1136/gut.2005.090415
M3 - Article
C2 - 16636018
AN - SCOPUS:33748930672
VL - 55
SP - 1789
EP - 1794
JO - Gut
JF - Gut
SN - 0017-5749
IS - 12
ER -