Translational approaches to functional platelet production ex vivo

Alessandra Balduini, Christian A Di Buduo, David L. Kaplan

Research output: Contribution to journalArticlepeer-review

Abstract

Platelets, which are released by megakaryocytes, play key roles in haemostasis, angiogenesis, immunity, tissue regeneration and wound healing. The scarcity of clinical cures for life threatening platelet diseases is in a large part due to limited insight into the mechanisms that control the developmental process of megakaryocytes and the mechanisms that govern the production of platelets within the bone marrow. To overcome these limitations, functional human tissue models have been developed and studied to extrapolate ex vivo outcomes for new insight on bone marrow functions in vivo. There are many challenges that these models must overcome, from faithfully mimicking the physiological composition and functions of bone marrow, to the collection of the platelets generated and validation of their viability and function for human use. The overall goal is to identify innovative instruments to study mechanisms of platelet release, diseases related to platelet production and new therapeutic targets starting from human progenitor cells.

Original languageEnglish
Pages (from-to)250-6
Number of pages7
JournalThrombosis and Haemostasis
Volume115
Issue number2
DOIs
Publication statusPublished - Jan 2016

Keywords

  • Animals
  • Biocompatible Materials
  • Bioengineering
  • Bioreactors
  • Blood Platelets
  • Bone Marrow
  • Bone Marrow Cells
  • Humans
  • Inflammation
  • Megakaryocytes
  • Phenotype
  • Stem Cells
  • Thrombopoiesis
  • Translational Medical Research
  • Treatment Outcome
  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

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