TY - JOUR
T1 - Translational insights and new therapeutic perspectives in head and neck tumors
AU - Fasano, Morena
AU - Perri, Francesco
AU - Corte, Carminia Maria Della
AU - Di Liello, Raimondo
AU - Scarpati, Giuseppina Della Vittoria
AU - Cascella, Marco
AU - Ottaiano, Alessandro
AU - Ciardiello, Fortunato
AU - Solla, Raffaele
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/8
Y1 - 2021/8
N2 - Head and neck squamous cell carcinoma (HNSCC) is characterized by a high mortality rate owing to very few available oncological treatments. For many years, a combination of platinum-based chemotherapy and anti-EGFR antibody cetuximab has represented the only available option for first-line therapy. Recently, immunotherapy has been presented an alternative for positive PD-L1 HNSCC. However, the oncologists’ community foresees that a new therapeutic era is approaching. In fact, no-chemo options and some molecular targets are on the horizon. This narrative review addresses past, present, and future therapeutic options for HNSCC from a translational point of view.
AB - Head and neck squamous cell carcinoma (HNSCC) is characterized by a high mortality rate owing to very few available oncological treatments. For many years, a combination of platinum-based chemotherapy and anti-EGFR antibody cetuximab has represented the only available option for first-line therapy. Recently, immunotherapy has been presented an alternative for positive PD-L1 HNSCC. However, the oncologists’ community foresees that a new therapeutic era is approaching. In fact, no-chemo options and some molecular targets are on the horizon. This narrative review addresses past, present, and future therapeutic options for HNSCC from a translational point of view.
KW - DNA damage response
KW - Epithelial growth factor receptor
KW - Head and neck squamous cell carcinoma
KW - Immunotherapy
UR - http://www.scopus.com/inward/record.url?scp=85113353084&partnerID=8YFLogxK
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U2 - 10.3390/biomedicines9081045
DO - 10.3390/biomedicines9081045
M3 - Review article
AN - SCOPUS:85113353084
VL - 9
JO - Biomedicines
JF - Biomedicines
SN - 2227-9059
IS - 8
M1 - 1045
ER -