Translational Mini-Review Series on Immunology of Vascular Disease: Mechanisms of vascular inflammation and remodelling in systemic vasculitis

N. Maugeri, P. Rovere-Querini, M. Baldini, M. G. Sabbadini, A. A. Manfredi

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Vessel walls are the primary inflammatory sites in systemic vasculitides. In most cases the initiating event is unknown, and a self-sustaining circuit attracts and activates inflammatory leucocytes in the wall of vessels of various size and anatomical characteristics. Recent studies have revealed homeostatic roles of vascular inflammation and have identified the action of humoral innate immunity, in particular injury-associated signals and acute phase proteins, on the activation of circulating leucocytes, platelets and endothelial cells. These advances have provided clues to the molecular mechanisms underlying the vicious circle that maintains and amplifies vessel and tissue injury.

Original languageEnglish
Pages (from-to)395-404
Number of pages10
JournalClinical and Experimental Immunology
Volume156
Issue number3
DOIs
Publication statusPublished - Jun 2009

Fingerprint

Systemic Vasculitis
Allergy and Immunology
Vascular Diseases
Leukocytes
Inflammation
Acute-Phase Proteins
Wounds and Injuries
Humoral Immunity
Innate Immunity
Blood Vessels
Blood Platelets
Endothelial Cells
Vascular Remodeling

Keywords

  • ANCA
  • Giant cell arteritis
  • HMGB1
  • PTX3
  • Vasculitis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

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AU - Sabbadini, M. G.

AU - Manfredi, A. A.

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