TY - JOUR
T1 - Translational research in cutaneous melanoma
T2 - New therapeutic perspectives
AU - Marra, Antonio
AU - Ferrone, Cristina R.
AU - Fusciello, Celeste
AU - Scognamiglio, Giosuè
AU - Ferrone, Soldano
AU - Pepe, Stefano
AU - Perri, Francesco
AU - Sabbatino, Francesco
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Melanoma is an aggressive form of skin cancer characterized by poor prognosis and high mortality. The development of targeted agents based on the discovery of driver mutations as well as the implementation of checkpoint inhibitor-based immunotherapy represents a major breakthrough in the treatment of metastatic melanoma. However, in both cases the development of drug resistance and immune escape mechanisms as well as the lack of predictive biomarkers limits their extraordinary clinical efficacy. In this article, we summarize the available therapeutic options for patients with metastatic melanoma, outline the mechanisms implicated in the resistance to both targeted agents and immunotherapy, discuss potential predictive biomarkers and outline future therapeutic approaches under investigation.
AB - Melanoma is an aggressive form of skin cancer characterized by poor prognosis and high mortality. The development of targeted agents based on the discovery of driver mutations as well as the implementation of checkpoint inhibitor-based immunotherapy represents a major breakthrough in the treatment of metastatic melanoma. However, in both cases the development of drug resistance and immune escape mechanisms as well as the lack of predictive biomarkers limits their extraordinary clinical efficacy. In this article, we summarize the available therapeutic options for patients with metastatic melanoma, outline the mechanisms implicated in the resistance to both targeted agents and immunotherapy, discuss potential predictive biomarkers and outline future therapeutic approaches under investigation.
KW - BRAF inhibitor resistance
KW - Immune checkpoint molecules
KW - Immunotherapy
KW - Immunotherapy resistance
KW - Melanoma
KW - PD-1
KW - PD-L1
KW - Predictive biomarkers
KW - Targeted therapy
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UR - http://www.scopus.com/inward/citedby.url?scp=85047624210&partnerID=8YFLogxK
U2 - 10.2174/1871520618666171219115335
DO - 10.2174/1871520618666171219115335
M3 - Review article
AN - SCOPUS:85047624210
VL - 18
SP - 166
EP - 181
JO - Anti-Cancer Agents in Medicinal Chemistry
JF - Anti-Cancer Agents in Medicinal Chemistry
SN - 1871-5206
IS - 2
ER -