Translational significance of Nodal, Cripto-1 and Notch4 in adult nevi

Luigi Strizzi, Naira V. Margaryan, Pedram Gerami, Zahra Haghighat, Paul W. Harms, Gabriele Madonna, Gerardo Botti, Paolo A. Ascierto, Mary J C Hendrix

Research output: Contribution to journalArticle

Abstract

The TGF-β associated growth factor Nodal is highly expressed in aggressive metastatic melanoma. Determining the risk for melanomagenesis from Nodal expression in nevi prior to the development of melanoma may be useful for both the screening and prevention of melanoma. Tissue sections of human adult nevi with or without a history of melanoma were stained by immunohistochemistry (IHC) for Nodal, the Nodal co-receptor Cripto-1, and Notch4, which have previously been shown to be associated with Nodal expression in melanoma. The degree of Nodal, Cripto-1 and Notch4 staining was scored and correlated with available clinical data. Median IHC scores for Nodal, Cripto-1 and Notch4 expression were significantly higher in nevi removed from patients who eventually developed melanoma compared with nevi from patients with no history of melanoma. In addition, the degree of Nodal expression in nevi from patients who eventually developed melanoma correlated significantly with the Breslow depth of the melanoma. Expression of Nodal and components of its signaling pathway in nevi may represent a biomarker for selecting a unique subset of patients requiring increased surveillance for screening and prevention of melanoma.

Original languageEnglish
Pages (from-to)1349-1354
Number of pages6
JournalOncology Letters
Volume12
Issue number2
DOIs
Publication statusPublished - Aug 1 2016

Keywords

  • Biomarker
  • Cripto-1
  • Immunohistochemistry
  • Melanoma
  • Nevus
  • Nodal
  • Notch4
  • Screening

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Strizzi, L., Margaryan, N. V., Gerami, P., Haghighat, Z., Harms, P. W., Madonna, G., Botti, G., Ascierto, P. A., & Hendrix, M. J. C. (2016). Translational significance of Nodal, Cripto-1 and Notch4 in adult nevi. Oncology Letters, 12(2), 1349-1354. https://doi.org/10.3892/ol.2016.4755