Translocation breakpoints are clustered on both chromosome 8 and chromosome 21 in the t(8;21) of acute myeloid leukemia

Jane E. Tighe, Antonio Daga, Franco Calabi

Research output: Contribution to journalArticlepeer-review

Abstract

The t(8;21)(q22;q22) is consistently associated with acute myeloid leukemia (AML) M2. Recent data have suggested that breakpoints on chromosome 21 are clustered within a single intron of a novel gene. AML1, just downstream of a region of homology to the runt gene of D melanogaster. In this report, we confirm rearrangement at the same location in at least 12 of 18 patients with t(8;21). Furthermore, we have isolated recombinant clones spanning the breakpoint regions on both the der(8) and the der(21) from one patient. By using a chromosome 8 probe derived from these clones, we show that t(8;21) breakpoints are also clustered on chromosome 8.

Original languageEnglish
Pages (from-to)592-596
Number of pages5
JournalBlood
Volume81
Issue number3
Publication statusPublished - Feb 1 1993

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Translocation breakpoints are clustered on both chromosome 8 and chromosome 21 in the t(8;21) of acute myeloid leukemia'. Together they form a unique fingerprint.

Cite this