Translocation-Related Sarcomas

Fredrik Mertens, Cristina R. Antonescu, Peter Hohenberger, Marc Ladanyi, Piergiorgio Modena, Maurizio D'Incalci, Paolo G. Casali, Massimo Aglietta, Thor Alvegård

Research output: Contribution to journalArticle

Abstract

Sarcomas with chromosomal translocations represent only about one fourth of sarcoma diagnoses. However, like gastrointestinal stromal tumor (GIST), with its characteristic KIT or PDGFRA mutations, they are particularly interesting since they provide specific biological insights and mechanisms of action that may have an impact upon prognosis or therapy. These are mechanisms we are just beginning to exploit. In this section we will review the biology and clinical impact of translocation-associated sarcomas and review the clinical findings that have made a recent impact upon patients with these diverse diagnoses.

Original languageEnglish
Pages (from-to)312-323
Number of pages12
JournalSeminars in Oncology
Volume36
Issue number4
DOIs
Publication statusPublished - Aug 2009

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ASJC Scopus subject areas

  • Oncology
  • Hematology

Cite this

Mertens, F., Antonescu, C. R., Hohenberger, P., Ladanyi, M., Modena, P., D'Incalci, M., Casali, P. G., Aglietta, M., & Alvegård, T. (2009). Translocation-Related Sarcomas. Seminars in Oncology, 36(4), 312-323. https://doi.org/10.1053/j.seminoncol.2009.06.004