Abstract
Sarcomas with chromosomal translocations represent only about one fourth of sarcoma diagnoses. However, like gastrointestinal stromal tumor (GIST), with its characteristic KIT or PDGFRA mutations, they are particularly interesting since they provide specific biological insights and mechanisms of action that may have an impact upon prognosis or therapy. These are mechanisms we are just beginning to exploit. In this section we will review the biology and clinical impact of translocation-associated sarcomas and review the clinical findings that have made a recent impact upon patients with these diverse diagnoses.
| Original language | English |
|---|---|
| Pages (from-to) | 312-323 |
| Number of pages | 12 |
| Journal | Seminars in Oncology |
| Volume | 36 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Aug 2009 |
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ASJC Scopus subject areas
- Oncology
- Hematology
Cite this
Translocation-Related Sarcomas. / Mertens, Fredrik; Antonescu, Cristina R.; Hohenberger, Peter; Ladanyi, Marc; Modena, Piergiorgio; D'Incalci, Maurizio; Casali, Paolo G.; Aglietta, Massimo; Alvegård, Thor.
In: Seminars in Oncology, Vol. 36, No. 4, 08.2009, p. 312-323.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Translocation-Related Sarcomas
AU - Mertens, Fredrik
AU - Antonescu, Cristina R.
AU - Hohenberger, Peter
AU - Ladanyi, Marc
AU - Modena, Piergiorgio
AU - D'Incalci, Maurizio
AU - Casali, Paolo G.
AU - Aglietta, Massimo
AU - Alvegård, Thor
PY - 2009/8
Y1 - 2009/8
N2 - Sarcomas with chromosomal translocations represent only about one fourth of sarcoma diagnoses. However, like gastrointestinal stromal tumor (GIST), with its characteristic KIT or PDGFRA mutations, they are particularly interesting since they provide specific biological insights and mechanisms of action that may have an impact upon prognosis or therapy. These are mechanisms we are just beginning to exploit. In this section we will review the biology and clinical impact of translocation-associated sarcomas and review the clinical findings that have made a recent impact upon patients with these diverse diagnoses.
AB - Sarcomas with chromosomal translocations represent only about one fourth of sarcoma diagnoses. However, like gastrointestinal stromal tumor (GIST), with its characteristic KIT or PDGFRA mutations, they are particularly interesting since they provide specific biological insights and mechanisms of action that may have an impact upon prognosis or therapy. These are mechanisms we are just beginning to exploit. In this section we will review the biology and clinical impact of translocation-associated sarcomas and review the clinical findings that have made a recent impact upon patients with these diverse diagnoses.
UR - http://www.scopus.com/inward/record.url?scp=67949088340&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67949088340&partnerID=8YFLogxK
U2 - 10.1053/j.seminoncol.2009.06.004
DO - 10.1053/j.seminoncol.2009.06.004
M3 - Article
C2 - 19664492
AN - SCOPUS:67949088340
VL - 36
SP - 312
EP - 323
JO - Seminars in Oncology
JF - Seminars in Oncology
SN - 0093-7754
IS - 4
ER -