Translocation, t(17;22)(q22;q13), in dermatofibrosarcoma protuberans: A new tumor-associated chromosome rearrangement

F. Pedeutour, M. P. Simon, F. Minoletti, G. Barcelo, M. J. Terrier-Lacombe, P. Combemale, G. Sozzi, N. Ayraud, C. Turc-Carel

Research output: Contribution to journalArticle

Abstract

A translocation, t(17;22)(q22;q13), was identified in two cases of dermatofibrosarcoma protuberans (DP). They bring to four the number of DP cases characterized by an identical t(17;22)(q22;q13), which can be considered as a new tumor-associated chromosome rearrangement. To date, this translocation has been found only in DP and its juvenile form, giant-cell fibroblastoma. This finding has two major consequences. First, it casts light on the development and significance in DP of ring chromosomes which consistently harbor sequences derived from chromosomes 17 and 22. Second, the identification of this new chromosome marker, and eventually of the underlying molecular rearrangement, should help to classify DP, a soft-tissue tumor of still uncertain cell origin. In addition, it could be used to differentiate DP from truly benign or malignant entities, in order that this tumor of intermediate malignancy could be adequately managed.

Original languageEnglish
Pages (from-to)171-174
Number of pages4
JournalCytogenetics and Cell Genetics
Volume72
Issue number2-3
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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    Pedeutour, F., Simon, M. P., Minoletti, F., Barcelo, G., Terrier-Lacombe, M. J., Combemale, P., Sozzi, G., Ayraud, N., & Turc-Carel, C. (1996). Translocation, t(17;22)(q22;q13), in dermatofibrosarcoma protuberans: A new tumor-associated chromosome rearrangement. Cytogenetics and Cell Genetics, 72(2-3), 171-174.