Translocation t(9;9)(p13;q34) in Philadelphia-negative chronic myeloid leukemia with breakpoint cluster region rearrangement

Mario Sessarego, Cristina Mareni, Renato Vimercati, Raffaella Defferrari, Paola Origone, Eugenio Damasio, Franco Ajmar

Research output: Contribution to journalArticlepeer-review

Abstract

Chromosome analysis showed a t(9;9)(p13;q34) in a patient with chronic myeloid leukemia (CML) without a Philadelphia (Ph) chromosome in all examined cells. Southern blot analysis of leukocyte DNA revealed rearrangement of breakpoint cluster region (bcr) within the 5.8-kb bcr sequences as in Ph-positive CML patients. The findings confirm that the 9q34 and 22q11 bands are always involved in CML independent of the chromosomal evidence. It is suggested that Ph-negative bcr-positive CML may have variant translocations, as in the case of the t(9;9) reported here.

Original languageEnglish
Pages (from-to)51-56
Number of pages6
JournalCancer Genetics and Cytogenetics
Volume43
Issue number1
DOIs
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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