Translocation t(9;9)(p13;q34) in Philadelphia-negative chronic myeloid leukemia with breakpoint cluster region rearrangement

Mario Sessarego; Cristina Mareni; Renato Vimercati; Raffaella Defferrari; Paola Origone; Eugenio Damasio; Franco Ajmar

doi:10.1016/0165-4608(89)90126-X

Translocation t(9;9)(p13;q34) in Philadelphia-negative chronic myeloid leukemia with breakpoint cluster region rearrangement

Mario Sessarego, Cristina Mareni, Renato Vimercati, Raffaella Defferrari, Paola Origone, Eugenio Damasio, Franco Ajmar

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

Chromosome analysis showed a t(9;9)(p13;q34) in a patient with chronic myeloid leukemia (CML) without a Philadelphia (Ph) chromosome in all examined cells. Southern blot analysis of leukocyte DNA revealed rearrangement of breakpoint cluster region (bcr) within the 5.8-kb bcr sequences as in Ph-positive CML patients. The findings confirm that the 9q34 and 22q11 bands are always involved in CML independent of the chromosomal evidence. It is suggested that Ph-negative bcr-positive CML may have variant translocations, as in the case of the t(9;9) reported here.

Original language	English
Pages (from-to)	51-56
Number of pages	6
Journal	Cancer Genetics and Cytogenetics
Volume	43
Issue number	1
DOIs	https://doi.org/10.1016/0165-4608(89)90126-X
Publication status	Published - 1989

ASJC Scopus subject areas

Cancer Research
Genetics
Molecular Biology

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Translocation t(9;9)(p13;q34) in Philadelphia-negative chronic myeloid leukemia with breakpoint cluster region rearrangement. / Sessarego, Mario; Mareni, Cristina; Vimercati, Renato; Defferrari, Raffaella; Origone, Paola; Damasio, Eugenio; Ajmar, Franco.

In: Cancer Genetics and Cytogenetics, Vol. 43, No. 1, 1989, p. 51-56.

Research output: Contribution to journal › Article › peer-review

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abstract = "Chromosome analysis showed a t(9;9)(p13;q34) in a patient with chronic myeloid leukemia (CML) without a Philadelphia (Ph) chromosome in all examined cells. Southern blot analysis of leukocyte DNA revealed rearrangement of breakpoint cluster region (bcr) within the 5.8-kb bcr sequences as in Ph-positive CML patients. The findings confirm that the 9q34 and 22q11 bands are always involved in CML independent of the chromosomal evidence. It is suggested that Ph-negative bcr-positive CML may have variant translocations, as in the case of the t(9;9) reported here.",

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AU - Damasio, Eugenio

AU - Ajmar, Franco

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AB - Chromosome analysis showed a t(9;9)(p13;q34) in a patient with chronic myeloid leukemia (CML) without a Philadelphia (Ph) chromosome in all examined cells. Southern blot analysis of leukocyte DNA revealed rearrangement of breakpoint cluster region (bcr) within the 5.8-kb bcr sequences as in Ph-positive CML patients. The findings confirm that the 9q34 and 22q11 bands are always involved in CML independent of the chromosomal evidence. It is suggested that Ph-negative bcr-positive CML may have variant translocations, as in the case of the t(9;9) reported here.

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