Transmembrane protein 106B gene (TMEM106B) variability and influence on progranulin plasma levels in patients with Alzheimer's disease

Maria Serpente, Chiara Fenoglio, Francesca Clerici, Rossana Bonsi, Beatrice Arosio, Sara M G Cioffi, Emanuela Rotondo, Massimo Franceschi, Filippo Martinelli Boneschi, Daniela Mari, Claudio Mariani, Elio Scarpini, Daniela Galimberti

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We carried out an association study of transmembrane protein 106B gene (TMEM106B) rs1020004 A/G, rs6966915C/T, and rs1990622 A/G in a population of 656 patients with Alzheimer's disease (AD) and 619 controls, and tested whether the rs1990622 influences plasma progranulin levels. No differences in allele and genotype distribution were observed between cases and controls, even stratifying according to APOE status (p > 0.05). No differences in progranulin plasma levels were found between carriers of the rs1990622 and non-carriers. TMEM106b variability does not influence AD risk or plasma levels. Replication, preferably in a population with pathological confirmation, is required to confirm these results.

Original languageEnglish
Pages (from-to)757-761
Number of pages5
JournalJournal of Alzheimer's Disease
Volume43
Issue number3
DOIs
Publication statusPublished - 2015

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Alzheimer Disease
Proteins
Population
Alleles
Genotype

Keywords

  • Alzheimer's disease
  • progranulin
  • TDP-43
  • TMEM106b

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Cite this

Transmembrane protein 106B gene (TMEM106B) variability and influence on progranulin plasma levels in patients with Alzheimer's disease. / Serpente, Maria; Fenoglio, Chiara; Clerici, Francesca; Bonsi, Rossana; Arosio, Beatrice; Cioffi, Sara M G; Rotondo, Emanuela; Franceschi, Massimo; Boneschi, Filippo Martinelli; Mari, Daniela; Mariani, Claudio; Scarpini, Elio; Galimberti, Daniela.

In: Journal of Alzheimer's Disease, Vol. 43, No. 3, 2015, p. 757-761.

Research output: Contribution to journalArticle

Serpente, Maria ; Fenoglio, Chiara ; Clerici, Francesca ; Bonsi, Rossana ; Arosio, Beatrice ; Cioffi, Sara M G ; Rotondo, Emanuela ; Franceschi, Massimo ; Boneschi, Filippo Martinelli ; Mari, Daniela ; Mariani, Claudio ; Scarpini, Elio ; Galimberti, Daniela. / Transmembrane protein 106B gene (TMEM106B) variability and influence on progranulin plasma levels in patients with Alzheimer's disease. In: Journal of Alzheimer's Disease. 2015 ; Vol. 43, No. 3. pp. 757-761.
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AU - Serpente, Maria

AU - Fenoglio, Chiara

AU - Clerici, Francesca

AU - Bonsi, Rossana

AU - Arosio, Beatrice

AU - Cioffi, Sara M G

AU - Rotondo, Emanuela

AU - Franceschi, Massimo

AU - Boneschi, Filippo Martinelli

AU - Mari, Daniela

AU - Mariani, Claudio

AU - Scarpini, Elio

AU - Galimberti, Daniela

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