Abstract
To evaluate the effects of in vivo β-IFN-1b treatment on transmigration of mononuclear cells, we monitored for one year in vitro mononuclear cells trafficking through HUVECs monolayers stratified over a collagen gel during β-IFN-1b treatment of 7 RR MS patients. The number of transmigrated cells was analysed before treatment (T0) and after 3 (T3), 6 (T6) and 12 months (T12); at the same time, levels of serum MMP-9 were quantified. The number of transmigrated cells decreased during treatment compared to pre-treatment values: the lowest number of transmigrated cells was detected at T3, and, although transmigration was still lower at T12, there was a trend to a return to pre-treatment levels over time. The amount of MMP-9 also decreased during therapy, although we could not find an absolute correlation between transmigration and levels of MMP-9, nor between either parameter and the clinical course of patients.
Original language | English |
---|---|
Pages (from-to) | 275-283 |
Number of pages | 9 |
Journal | Autoimmunity |
Volume | 33 |
Issue number | 4 |
Publication status | Published - 2001 |
Keywords
- β-IFN
- MMP-9
- Multiple sclerosis
- Transmigration
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology