Transmission disequilibrium study of an oligodendrocyte and myelin glycoprotein gene allele in 431 families with an autistic proband

Isabelle Martin, Julie Gauthier, Marcello D'Amelio, Sylviane Védrine, Patrick Vourc'h, Guy A. Rouleau, Antonio M. Persico, Christian R. Andres

Research output: Contribution to journalArticlepeer-review

Abstract

Autistic disorder is a neurodevelopmental disorder where genetic factors play an important role. We previously described an association between a subgroup of French autistic patients and an allele of a non-synonymous single nucleotide polymorphism (nsSNP: OMGP62 G > A or rs11080149) in the gene coding for the oligodendrocyte and myelin glycoprotein (OMG), located at 7 Mb from the marker D17S250, linked to autism in two independent genome scan studies. We report a study on 431 families with 1 affected child from different origins: French Canada (n = 262), Italy (n = 123) and United States (n = 46). We analyzed the transmission of the rs11080149 alleles from parents to their affected children. There was a preferential transmission of the G allele from parents to affected children (p = 0.0017) in the overall sample. Paternal and maternal transmission rates were both skewed. Taking into account our previous results obtained in a French group of patients, where we observed an association with allele A, a direct role of this polymorphism is improbable in autism. The associations observed in Japanese and French patients, the linkage studies and the present work speak in favor of the existence of a susceptibility gene for autism in the NF1 locus.

Original languageEnglish
Pages (from-to)426-430
Number of pages5
JournalNeuroscience Research
Volume59
Issue number4
DOIs
Publication statusPublished - Dec 2007

Keywords

  • 17q11 autism locus
  • Autistic disorder
  • Oligodendrocyte and myelin glycoprotein gene (OMG)
  • rs11080149 polymorphism
  • Transmission disequilibrium test

ASJC Scopus subject areas

  • Neuroscience(all)

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