Transmission of prions

Charles Weissmann, M. Enari, P. C. Klöhn, D. Rossi, E. Flechsig

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The "protein only" hypothesis holds that the infectious agent causing transmissible spongiform encephalopathies is a conformational isomer of PrP, a host protein that is predominantly expressed in the brain. This hypothesis is strongly supported by many lines of evidence. To date, prion diseases are unique among conformational diseases in that they are transmissible - experimentally and by natural routes (mainly by ingestion). The pathway of prions to the brain has been elucidated in outline. A striking feature of prions is their extraordinary resistance to conventional sterilization procedures and their capacity to bind to surfaces of metal and plastic without losing infectivity. This property, first observed in a clinical setting, is now being investigated in experimental settings, both in animals and in cell culture.

Original languageEnglish
JournalJournal of Infectious Diseases
Volume186
Issue numberSUPPL. 2
DOIs
Publication statusPublished - Dec 1 2002

Fingerprint

Prion Diseases
Prions
Brain
Plastics
Proteins
Cell Culture Techniques
Eating
Metals

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Weissmann, C., Enari, M., Klöhn, P. C., Rossi, D., & Flechsig, E. (2002). Transmission of prions. Journal of Infectious Diseases, 186(SUPPL. 2). https://doi.org/10.1086/344575

Transmission of prions. / Weissmann, Charles; Enari, M.; Klöhn, P. C.; Rossi, D.; Flechsig, E.

In: Journal of Infectious Diseases, Vol. 186, No. SUPPL. 2, 01.12.2002.

Research output: Contribution to journalArticle

Weissmann, C, Enari, M, Klöhn, PC, Rossi, D & Flechsig, E 2002, 'Transmission of prions', Journal of Infectious Diseases, vol. 186, no. SUPPL. 2. https://doi.org/10.1086/344575
Weissmann C, Enari M, Klöhn PC, Rossi D, Flechsig E. Transmission of prions. Journal of Infectious Diseases. 2002 Dec 1;186(SUPPL. 2). https://doi.org/10.1086/344575
Weissmann, Charles ; Enari, M. ; Klöhn, P. C. ; Rossi, D. ; Flechsig, E. / Transmission of prions. In: Journal of Infectious Diseases. 2002 ; Vol. 186, No. SUPPL. 2.
@article{1646d62ffc3a49999013cca1979bad73,
title = "Transmission of prions",
abstract = "The {"}protein only{"} hypothesis holds that the infectious agent causing transmissible spongiform encephalopathies is a conformational isomer of PrP, a host protein that is predominantly expressed in the brain. This hypothesis is strongly supported by many lines of evidence. To date, prion diseases are unique among conformational diseases in that they are transmissible - experimentally and by natural routes (mainly by ingestion). The pathway of prions to the brain has been elucidated in outline. A striking feature of prions is their extraordinary resistance to conventional sterilization procedures and their capacity to bind to surfaces of metal and plastic without losing infectivity. This property, first observed in a clinical setting, is now being investigated in experimental settings, both in animals and in cell culture.",
author = "Charles Weissmann and M. Enari and Kl{\"o}hn, {P. C.} and D. Rossi and E. Flechsig",
year = "2002",
month = "12",
day = "1",
doi = "10.1086/344575",
language = "English",
volume = "186",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "SUPPL. 2",

}

TY - JOUR

T1 - Transmission of prions

AU - Weissmann, Charles

AU - Enari, M.

AU - Klöhn, P. C.

AU - Rossi, D.

AU - Flechsig, E.

PY - 2002/12/1

Y1 - 2002/12/1

N2 - The "protein only" hypothesis holds that the infectious agent causing transmissible spongiform encephalopathies is a conformational isomer of PrP, a host protein that is predominantly expressed in the brain. This hypothesis is strongly supported by many lines of evidence. To date, prion diseases are unique among conformational diseases in that they are transmissible - experimentally and by natural routes (mainly by ingestion). The pathway of prions to the brain has been elucidated in outline. A striking feature of prions is their extraordinary resistance to conventional sterilization procedures and their capacity to bind to surfaces of metal and plastic without losing infectivity. This property, first observed in a clinical setting, is now being investigated in experimental settings, both in animals and in cell culture.

AB - The "protein only" hypothesis holds that the infectious agent causing transmissible spongiform encephalopathies is a conformational isomer of PrP, a host protein that is predominantly expressed in the brain. This hypothesis is strongly supported by many lines of evidence. To date, prion diseases are unique among conformational diseases in that they are transmissible - experimentally and by natural routes (mainly by ingestion). The pathway of prions to the brain has been elucidated in outline. A striking feature of prions is their extraordinary resistance to conventional sterilization procedures and their capacity to bind to surfaces of metal and plastic without losing infectivity. This property, first observed in a clinical setting, is now being investigated in experimental settings, both in animals and in cell culture.

UR - http://www.scopus.com/inward/record.url?scp=0036891080&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036891080&partnerID=8YFLogxK

U2 - 10.1086/344575

DO - 10.1086/344575

M3 - Article

VL - 186

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - SUPPL. 2

ER -