Transmitted drug resistant HIV-1 and association with virologic and CD4 cell count response to combination antiretroviral therapy in the euroSIDA study

Wendy P. Bannister, Alessandro Cozzi-Lepri, Bonaventura Clotet, Amanda Mocroft, Jesper Kjær, Peter Reiss, Viktor Von Wyl, Adriano Lazzarin, Christine Katlama, Andrew N. Phillips, Lidia Ruiz, Jens D. Lundgren

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: To investigate prevalence of transmitted drug-resistant human immunodeficiency virus (TDR) and factors associated with TDR and to compare virological and CD4 count response to combination antiretroviral therapy. METHODS: In this study, 525 mostly chronically infected EuroSIDA patients were included who had genotypic resistance tests performed on plasma samples collected while antiretroviral therapy naive. TDR was defined as at least one resistance mutation from a list proposed for genotypic TDR surveillance. Multivariable logistic regression was used to analyze factors associated with detection of TDR, with virological (viral load

Original languageEnglish
Pages (from-to)324-333
Number of pages10
JournalJournal of Acquired Immune Deficiency Syndromes
Volume48
Issue number3
DOIs
Publication statusPublished - Jul 1 2008

Keywords

  • Antiretroviral therapy
  • CD4
  • HIV drug resistance/resistance mutations
  • Viral load

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)
  • Virology
  • Immunology

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    Bannister, W. P., Cozzi-Lepri, A., Clotet, B., Mocroft, A., Kjær, J., Reiss, P., Wyl, V. V., Lazzarin, A., Katlama, C., Phillips, A. N., Ruiz, L., & Lundgren, J. D. (2008). Transmitted drug resistant HIV-1 and association with virologic and CD4 cell count response to combination antiretroviral therapy in the euroSIDA study. Journal of Acquired Immune Deficiency Syndromes, 48(3), 324-333. https://doi.org/10.1097/QAI.0b013e31817ae5c0