Transmitted HIV type 1 drug resistance and non-B subtypes prevalence among seroconverters and newly diagnosed patients from 1992 to 2005 in Italy

Chiara Riva, Alessia Lai, Ilaria Caramma, Stefano Corvasce, Michela Violin, Lorenzo Dehò, Francesca Prati, Cristina Rossi, Maria Chiara Colombo, Amedeo Capetti, Marco Franzetti, Valeria Rossini, Giuseppe Tambussi, Massimo Ciccozzi, Barbara Suligoi, Cristina Mussini, Giovanni Rezza, Claudia Balotta

Research output: Contribution to journalArticle

Abstract

The patterns of transmitted drug-resistant (TDR) HIV-1 variants, non-B subtype spread, and epidemiological trends were evaluated either in seroconverters or in newly diagnosed individuals in Italy over a 13-year period. We analyzed 119 seroconverters, enrolled from 1992 to 2003 for the CASCADE study, and 271 newly diagnosed individuals of the SPREAD study (2002-2005), of whom 42 had a known seroconversion date. Overall, TDR was 15.1% in the CASCADE and 12.2% in the SPREAD study. In the 1992-2003 period, men having sex with men (MSMs) and heterosexuals (HEs) were 48.7% and 36.8%, respectively; TDR was found to be higher in MSMs compared to HEs (78.9% vs. 21%, p = 0.006). The same groups were 39.1% and 53.3% in the SPREAD study; however, no association was detected between modality of infection and TDR. Overall, 9.2% and 22.1% of individuals harbored a non-B clade virus in the CASCADE and SPREAD study, respectively. As evidence of onward transmission, 40% (24/60) of non-B variants were carried by European individuals in the latter study; among these patients the F1 subtype was highly prevalent (p = 0.00001). One of every eight patients who received a diagnosis of HIV-1 in recent years harbored a resistant variant, reinforcing the arguments for baseline resistance testing to customize first-line therapy in newly infected individuals. The spread of non-B clades may act as a dilution factor of TDR concealing the proportion of TDR in seroconverters and MSMs.

Original languageEnglish
Pages (from-to)41-49
Number of pages9
JournalAIDS Research and Human Retroviruses
Volume26
Issue number1
DOIs
Publication statusPublished - Jan 1 2010

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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    Riva, C., Lai, A., Caramma, I., Corvasce, S., Violin, M., Dehò, L., Prati, F., Rossi, C., Colombo, M. C., Capetti, A., Franzetti, M., Rossini, V., Tambussi, G., Ciccozzi, M., Suligoi, B., Mussini, C., Rezza, G., & Balotta, C. (2010). Transmitted HIV type 1 drug resistance and non-B subtypes prevalence among seroconverters and newly diagnosed patients from 1992 to 2005 in Italy. AIDS Research and Human Retroviruses, 26(1), 41-49. https://doi.org/10.1089/aid.2009.0057