Transmitter release associated with long-term synaptic depression in rat corticostriatal slices

P. Calabresi, E. Fedele, A. Pisani, G. Fontana, N. B. Mercuri, G. Bernardi, M. Raiteri

Research output: Contribution to journalArticlepeer-review

Abstract

Using a corticostriatal slice preparation, we have recently shown that tetanic stimulation of the corticostriatal pathway produces long-term depression (LTD) of striatal excitatory synaptic transmission. In the present study we have analysed the relationship between LTD and the striatal release of different endogenous transmitters. Samples of perfusate were collected via a small cannula placed just above the surface of the striatal slice close to the recording electrode, and were analysed by HPLC. The high-frequency stimulation (100 Hz, three trains, 3 s duration, 20 s intervals) used to induce LTD caused a significant but transient increase in the release of both excitatory (aspartate and glutamate) and inhibitory (glycine and GABA) amino acid transmitters. Tetanic stimulation also produced a significant, but transient increase in the release of endogenous dopamine. We conclude that the tetanic stimulation of the corticostriatal pathway is able to induce a large but transient release of excitatory amino acids and of dopamine, whose participation in the induction of striatal LTD has been demonstrated previously. Moreover, the maintenance of this form of synaptic plasticity does not seem to require a sustained change in transmitter release.

Original languageEnglish
Pages (from-to)1889-1894
Number of pages6
JournalEuropean Journal of Neuroscience
Volume7
Issue number9
DOIs
Publication statusPublished - 1995

Keywords

  • Basal ganglia
  • Dopamine
  • Excitatory amino acids
  • GABA
  • Glycine
  • Learning
  • Striatum
  • Synaptic plasticity

ASJC Scopus subject areas

  • Neuroscience(all)

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