Transperineal Laser Ablation for Percutaneous Treatment of Benign Prostatic Hyperplasia: A Feasibility Study

Gianluigi Patelli, Antonio Ranieri, Aurelio Paganelli, Giovanni Mauri, Claudio Maurizio Pacella

Research output: Contribution to journalArticlepeer-review


Purpose: To assess the feasibility and safety of transperineal laser ablation (TPLA) for treating benign prostatic hyperplasia (BPH). Materials and Methods: Institutional review board approval was obtained for this prospective non-randomized trial. Eightteen patients (age 71.7 ± 9.4 years) with urinary symptoms secondary to BPH underwent TPLA under local anesthesia. Under US guidance, up to four 21G applicators were inserted in the prostatic tissue. Each treatment was performed with diode laser operating at 1064 nm changing the illumination time according to prostate size. Primary endpoints were technical success and safety of TPLA. Secondary endpoints included operation time, ablation time, energy deployed, hospitalization time, catheterization time, and change in International Prostate Symptom Score (IPSS), Quality of Life (QoL), peak urinary flow rate (Qmax), post-void residual (PVR), and prostatic volume at 3 months. χ2 and Fisher exact tests were used. Results: All procedures were technically successful. No complications occurred. Mean operation time was 43.3 ± 8.7 min, mean ablation time 15.9 ± 3.9 min, mean energy deployed 10,522 ± 3290.5 J, mean hospital stay 1.5 ± 0.4 days, and mean catheterization time 17.3 ± 10.0 days. At 3 months, IPSS improved from 21.9 to 10.7 (P < 0.001), QoL from 4.7 ± 0.6 to 2.1 ± 1.2 (P < 0.001), Qmax from 7.6 to 13.3 mL/s (P = 0.001), PVR from 199.9 ± 147.3 to 81.5 ± 97.8 (P < 0.001), and mean prostate volume from 69.8 to 54.8 mL (P < 0.001). Conclusions: TPLA is feasible and safe in the treatment of BPH, providing significant clinical results at 3 months. Level of Evidence: Case series, Level IV.

Original languageEnglish
Pages (from-to)1440-1446
Number of pages7
JournalCardioVascular and Interventional Radiology
Issue number9
Publication statusPublished - Sep 1 2017


  • Ablation
  • Image guidance
  • Laser
  • Minimally invasive treatments
  • Prostate

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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