Transperitoneal fludi dynamics in rabbit liver

D. Negrini, C. Gonano, M. Del Fabbro, G. Miserocchi

Research output: Contribution to journalArticlepeer-review


The peritoneal cavity of 18 anesthetized spontaneously breathing supine rabbits was opened through a midline section. One or two hollow capsules (surface area 0.8 cm2) were glued to the exposed liver surface, filled with whole or 25% diluted plasma, and connected to a transducer and a graduated pipette. Various hydraulic pressures (Pcap) were set in the capsule; at each Pcap the liquid flow per unit surface area (V̇/S) between the Disse's interstitial space and the capsule was measured from the rate of liquid displacement in the pipette. The slope of the V̇/S vs. Pcap linear regression was utilized to estimate the hydraulic conductivity of the Glissonian-peritoneal membrane and averaged 5.1 x 10-3 ± 4.7 x 10-3 (SD) ml·h-1·cmH2O-1·cm-2 (n = 25). Hydraulic pressure in the Disse's space (Pd) was measured by closing the capsule against the transducer disconnected from the pipette. At portal and hepatic venous pressures of 7.6 ± 2.9 and 2.6 ± 1 cmH2O, respectively, Pd was 20.5 ± 2 cmH2O. Physiologically, Starling pressure gradients cause fluid transfer from the sinusoids to the Disse's space; transperitoneal fluid filtration only occurs through the liver surface that faces the diaphragm, which corresponds to one-fifth of the total hepatic surface.

Original languageEnglish
Pages (from-to)625-629
Number of pages5
JournalJournal of Applied Physiology
Issue number2
Publication statusPublished - 1990


  • hepatic interstitial pressure
  • hydraulic conductivity
  • peritoneal liquid turnover
  • serous spaces liquid turnover

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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