Transplacental exposure to environmental carcinogens: Association with childhood cancer risks and the role of modulating factors

A. Fucic, V. Guszak, A. Mantovani

Research output: Contribution to journalReview article

Abstract

Biological responses to carcinogens from environmental exposure during adulthood are modulated over years or decades. Conversely, during transplacental exposure, the effects on the human foetus change within weeks, intertwining with developmental mechanisms: even short periods of transplacental exposure may be imprinted in the organism for a lifetime. The pathways leading to childhood and juvenile cancers, such as leukaemias, neuroblastoma/brain tumours, hepatoblastoma, and Willm's tumour involve prenatally-induced genomic, epigenomic and/or non-genomic effects caused by xenobiotics. Pregnant women most often live in complex environmental settings that cause transplacental exposure of the foetus to xenobiotic mixtures. Mother-child biomonitoring should integrate the analysis of chemicals/radiation present in the living and workplace environment with relevant risk modulators related to life style. The interdisciplinary approach for transplacental cancer risk assessment in high-pressure areas should be based on an integrated model for mother-child exposure estimation via profiling the exposure level by water quality analysis, usage of emission grids, and land use maps.

Original languageEnglish
Pages (from-to)182-190
Number of pages9
JournalReproductive Toxicology
Volume72
DOIs
Publication statusPublished - Sep 1 2017

Keywords

  • Air pollution
  • Childhood cancer
  • Food
  • Juvenile cancer
  • Newborn
  • Pesticides
  • Sex-related susceptibility
  • Transplacental

ASJC Scopus subject areas

  • Toxicology

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