Transplacental transfer of antiretroviral drugs and newborn birth weight in HIV-infected pregnant women

Jelena Ivanovic, Emanuele Nicastri, Maurizio M. Anceschi, Paolo Ascenzi, Fabrizio Signore, Giuseppe Pisani, Cristina Vallone, Elisabetta Mattia, Stefania Notari, Massimo Tempestilli, Leopoldo P. Pucillo, Pasquale Narciso, Rita Bellagamba, Giuseppina Liuzzi, Valerio Tozzi, Patrizio De Longis, Pietro Sette, Adriana Ammassari, Gianfranco Anzidei, Evangelo BoumisPierangelo Ghinello, Chiara Tommasi, Letizia Giancola

Research output: Contribution to journalArticlepeer-review


Although it is well known that antiretroviral drugs (ARVs) across the placenta in different extents, few data are available concerning the impact of the transplacental passage of ARVs on newborn outcome. The aim of this study is to evaluate the transplacental diffusion of ARVs and the clinical assessment of the newborn. Mother and cord lopinavir, nelfinavir, atazanavir and nevirapine plasma levels were determined by high-performance liquid chromatography. Newborn gestational age, weight, and Apgar score were recorded. Cord-to-mother ratio (C:M) was calculated to estimate the placental passage of ARVs. Preterm birth was defined as delivery at

Original languageEnglish
Pages (from-to)620-625
Number of pages6
JournalCurrent HIV Research
Issue number6
Publication statusPublished - Nov 2009


  • Cord-to-mother blood ratio
  • Low birth weight
  • Pregnancy
  • TDM

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology


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