Transplantation activities and treatment strategies in paediatric stem cell transplantation centres: A report from the EBMT Working Party on Paediatric Diseases

C. Peters, R. Ladenstein, M. Minkov, U. Pötschger, H. Gadner, J. Cornish, G. Dini, T. Klingebiel, F. Locatelli, J. Vossen, D. Niethammer

Research output: Contribution to journalArticle

Abstract

To determine the current approach to stem cell transplantation (SCT) in centres which treat predominantly paediatric patients, a questionnaire was sent to 67 centres known by the EBMT registry to perform SCT mainly in children. Fifty-five centres from 19 countries responded. Forty centres (75%) started their transplantation activities between 1980 and 1992. Median number of transplants/centre was 95 (range 8-400). Median number of transplants/centre/year was 18 (range 5-85). On average, there was one physician responsible for seven SCT/year while one nurse was involved for a median of 1.7 SCT/year. Median four rooms/centre (range 1-17) were available for paediatric SCT. The most common isolation facilities were rooms with high efficiency particulate air filtration (HEPA). Eighty-two percent (45/55) of the centres performed allogeneic as well as autologous SCT, while 5% (three centres) offered exclusively allogeneic SCT and 13% (seven centres) used only autologous stem cell rescue. Stem cell source for allogeneic SCT was bone marrow in 87%, peripheral blood (PB) in 10% and umbilical cord blood in 3%. Donors were HLA matched related in 57%, mismatched related in 13%, and matched unrelated in 30% of allogeneic SCT. PB was the most commonly used stem cell source for autologous SCT (48%), followed by BM (41%) and the two together (11%). Data analysis revealed substantial differences in protective care, stem cell processing and transplantation procedures within the centres, irrespective of the country, centre size and transplant type.

Original languageEnglish
Pages (from-to)431-437
Number of pages7
JournalBone Marrow Transplantation
Volume22
Issue number5
Publication statusPublished - 1998

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Keywords

  • Blood cell support
  • Bone marrow harvesting
  • Children
  • Isolation rooms
  • Staff
  • Stem cell transplantation

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Peters, C., Ladenstein, R., Minkov, M., Pötschger, U., Gadner, H., Cornish, J., Dini, G., Klingebiel, T., Locatelli, F., Vossen, J., & Niethammer, D. (1998). Transplantation activities and treatment strategies in paediatric stem cell transplantation centres: A report from the EBMT Working Party on Paediatric Diseases. Bone Marrow Transplantation, 22(5), 431-437.