Abstract
Hematopoietic reconstitution after transplantation relies on a small number of hematopoietic stem cells that selectively migrate from the bloodstream to the hematopoietic microenvironment. In the first phase of engraftment, an extreme proliferative demand causes a limited stem cell fraction and its progeny to divide continuously, showing a significant telomere shortening. When all hematopoietic compartments are fully reconstituted, progenitor cell replication stabilizes and the stem cell pool reverts to a quiescent state. In transplant recipients, the hematopoietic microenvironment and stem cell reservoir remain defective for a prolonged period. However, in most patients donor-derived polyclonal hemopoiesis results, and the system is not exhausted but is capable of sustained normal counts and eventually overcomes stressed conditions.
| Original language | English |
|---|---|
| Pages (from-to) | 331-336 |
| Number of pages | 6 |
| Journal | Current Opinion in Hematology |
| Volume | 8 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2001 |
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ASJC Scopus subject areas
- Hematology
Cite this
Transplantation hematopoiesis. / Podestà, Marina.
In: Current Opinion in Hematology, Vol. 8, No. 6, 2001, p. 331-336.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Transplantation hematopoiesis
AU - Podestà, Marina
PY - 2001
Y1 - 2001
N2 - Hematopoietic reconstitution after transplantation relies on a small number of hematopoietic stem cells that selectively migrate from the bloodstream to the hematopoietic microenvironment. In the first phase of engraftment, an extreme proliferative demand causes a limited stem cell fraction and its progeny to divide continuously, showing a significant telomere shortening. When all hematopoietic compartments are fully reconstituted, progenitor cell replication stabilizes and the stem cell pool reverts to a quiescent state. In transplant recipients, the hematopoietic microenvironment and stem cell reservoir remain defective for a prolonged period. However, in most patients donor-derived polyclonal hemopoiesis results, and the system is not exhausted but is capable of sustained normal counts and eventually overcomes stressed conditions.
AB - Hematopoietic reconstitution after transplantation relies on a small number of hematopoietic stem cells that selectively migrate from the bloodstream to the hematopoietic microenvironment. In the first phase of engraftment, an extreme proliferative demand causes a limited stem cell fraction and its progeny to divide continuously, showing a significant telomere shortening. When all hematopoietic compartments are fully reconstituted, progenitor cell replication stabilizes and the stem cell pool reverts to a quiescent state. In transplant recipients, the hematopoietic microenvironment and stem cell reservoir remain defective for a prolonged period. However, in most patients donor-derived polyclonal hemopoiesis results, and the system is not exhausted but is capable of sustained normal counts and eventually overcomes stressed conditions.
UR - http://www.scopus.com/inward/record.url?scp=0034760881&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034760881&partnerID=8YFLogxK
U2 - 10.1097/00062752-200111000-00003
DO - 10.1097/00062752-200111000-00003
M3 - Article
C2 - 11604571
AN - SCOPUS:0034760881
VL - 8
SP - 331
EP - 336
JO - Current Opinion in Hematology
JF - Current Opinion in Hematology
SN - 1065-6251
IS - 6
ER -