Transplantation in the onco-hematology field: Focus on the manipulation of αβ and γδ T cells

Nicola Daniele, Maria Cristina Scerpa, Maurizio Caniglia, Maria Ester Bernardo, Cecilia Rossi, Chiara Ciammetti, Giuseppe Palumbo, Franco Locatelli, Giancarlo Isacchi, Francesco Zinno

Research output: Contribution to journalArticlepeer-review

Abstract

γ/δ T cells represent a subset of T cells expressing a T cell receptor (TCR) variant composed of gamma and delta chains. The γ/δ TCR is expressed by 2-10% of all T cells in human peripheral blood, whereas the majority of T cells express α/β TCRsγ/δ T cells display a range of innate effector functions including rapid secretion of chemokines and cytokines, as well as target cell lysis. Recent interest has focused on the function of γ/δ T lymphocytes in allogeneic transplantation in the onco-hematology field. Several studies, in vitro and in vivo, suggest that γ/δ T lymphocytes are potential beneficial effector cells in the context of hematopoietic stem cell transplantation (HSCT). In addition, in this review, we discuss the depletion of α/β T lymphocytes in the graft for allogeneic transplantation. In fact, an efficient TCR α/β cell depletion potentially reduces the risk of GvHD. Furthermore, TCR α/β T cell depletion, especially with immunomagnetic negative selection, retains other potential beneficial effector cells in the graft, such as γ/δ T cells, NK cells, and stem cells. These " facilitating" cells might facilitate engraftment, exert GvL effects, and reduce the risk for infections.

Original languageEnglish
Pages (from-to)67-73
Number of pages7
JournalPathology Research and Practice
Volume208
Issue number2
DOIs
Publication statusPublished - Feb 15 2012

Keywords

  • αβ T cells
  • γδ T cells
  • Allogeneic transplantation
  • T cell depletion

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology

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