Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia

Vanderson Rocha, Myriam Labopin, Guillermo Sanz, William Arcese, Rainer Schwerdtfeger, Alberto Bosi, Niels Jacobsen, Tapani Ruutu, Marcos De Lima, Jürgen Finke, Francesco Frassoni, Eliane Gluckman

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Promising results of cord-blood transplants from unrelated donors have been reported in adults. METHODS: We compared outcomes in 682 adults with acute leukemia who received a hematopoietic stem-cell transplant from an unrelated donor: 98 received cord blood and 584 received bone marrow. The transplantations were performed from 1998 through 2002 and reported to Eurocord and the European Blood and Marrow Transplant Group. RESULTS: Recipients of cord blood were younger than recipients of bone marrow (median, 24.5 vs. 32 years of age; P8 per kilogram of the recipient's body weight for cord blood and 2.9×10 8 per kilogram for bone marrow (P

Original languageEnglish
Pages (from-to)2276-2285
Number of pages10
JournalNew England Journal of Medicine
Volume351
Issue number22
DOIs
Publication statusPublished - Nov 25 2004

ASJC Scopus subject areas

  • Medicine(all)

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    Rocha, V., Labopin, M., Sanz, G., Arcese, W., Schwerdtfeger, R., Bosi, A., Jacobsen, N., Ruutu, T., De Lima, M., Finke, J., Frassoni, F., & Gluckman, E. (2004). Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. New England Journal of Medicine, 351(22), 2276-2285. https://doi.org/10.1056/NEJMoa041469