Mielopatie acute in presenza di anti-corpi anti-fosfolipidi. Presentazione di 4 casi clinici

Translated title of the contribution: Transverse myelitis associated with anti-phospholipid antibodies. Clinical reports of 4 patients

B. Colombo, F. Martinelli, P. Rossi, G. Comi

Research output: Contribution to journalArticle

Abstract

Anti-phospholipid syndrome is defined by widespread arterial and venous thrombosis in association with high hematological titers of anti-phospholidid antibodies. These vascular events could involve, although rarely, also the spinal cord and determine acute myelopathy (in accordance with Jeffery's criteria). In this paper we reported the clinical history of four patients affected by the anti-phospholipid syndrome who presented to our clinics for the appearance of a myelopathic disorder. Anti-phospholid syndrome should be always considered in the differential diagnosis between the possible causes of myelopathy. Among them, the most important are: systemic lupus erythematosus; infections (viral, bacterial or fungine); neoplasms; compressive origin; inflammatory and demyelinization (multiple sclerosis). The most useful clues for the diagnosis we found in our clinical practice are the clinical evaluation of the patient and the course of pathology during time; hematological evaluation of anti-phospholid antibodies; CSF and magnetic resonance imaging of the brain and of the spinal cord. An early diagnosis of the anti-phospholid syndrome is really important for the different therapeutical approach which needs, based on the daily use of anti- aggregant drugs, anti-coagulant and immunosuppressor.

Original languageItalian
Pages (from-to)411-419
Number of pages9
JournalRivista di Neurobiologia
Volume43
Issue number5
Publication statusPublished - 1997

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Transverse Myelitis
Antiphospholipid Syndrome
Spinal Cord Diseases
Anti-Idiotypic Antibodies
Phospholipids
Spinal Cord
Coagulants
Virus Diseases
Bacterial Infections
Venous Thrombosis
Systemic Lupus Erythematosus
Multiple Sclerosis
Blood Vessels
Early Diagnosis
Differential Diagnosis
History
Magnetic Resonance Imaging
Pathology
Brain
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Mielopatie acute in presenza di anti-corpi anti-fosfolipidi. Presentazione di 4 casi clinici. / Colombo, B.; Martinelli, F.; Rossi, P.; Comi, G.

In: Rivista di Neurobiologia, Vol. 43, No. 5, 1997, p. 411-419.

Research output: Contribution to journalArticle

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