Trasmissione verticale del virus dell'epatite c da madre a figlio: Valutazione della frequenza e dei fattori di rischio

C. Perone, M. Rotondi, A. Ranieri, C. Lauro, C. Borzacchiello, S. Panariello

Research output: Contribution to journalArticlepeer-review


Hepatitis C virus (HCV) is the principal cause of nAnB hepatitis and it is associated to an high incidence of chronic hepatitis, cirrosis and hepatocellular cancer. Other sources of infection apart from the well-known (blood trasfusion, injection of drugs and surgery) are represented by sexual transmission and perinatal vertical transmission. The aim of our work is to resume and analyze different data reported in literature about mechanisms of transmission of the virus, focusing our attention on the vertical perinatal way. The vertical perinatal way accounts for a small percentage (from 0 to 18% among different Authors) of pregnant women affected by HCV infection. Several conditions have been recognized to be risk-factors for the transmission of the virus to the new-born: HCV-Ab and HCV-RNA plasma levels of the mother, coinfection of HIV, euthocic delivery and breast-feeding. Though several reports have been published, data on the relative importance of every single risk-factor are still somehow conflicting in assessing the most important cause of mother to son transmission of HCV.

Original languageItalian
JournalGiornale Italiano di Ostetricia e Ginecologia
Issue number6
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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