Lo scompenso cardiaco da trastuzumab nel trattamento del tumore al seno

Translated title of the contribution: Trastuzumab-induced heart failure in the treatment of breast cancer

Luigi Tarantini, Mauro Feola, Adriana Albini, Stefania Gori, Jennifer Foglietta, Maria Antonietta Cicoira, Giovanni Pulignano

Research output: Contribution to journalArticle

Abstract

The amplification of the HER receptor system is present in approximately 20% of breast cancers and confers a marked malignancy and a poor prognosis. Trastuzumab, a monoclonal antibody directed against the HER2 receptor, has dramatically improved the prognosis of patients with HER2+ metastatic and early breast cancer. However, the use of trastuzumab is associated with the possible development of myocardial dysfunction and heart failure. Trastuzumab-induced cardiac injury may be reversible, and a substantial proportion of patients can complete therapy. For this reason, careful monitoring of cardiac function, an aggressive treatment of hypertension and possibly the use of non-anthracycline-containing chemotherapy protocols are required during trastuzumab treatment. Owing to the selection of patients enrolled in major randomized trials, the safety profile of trastuzumab is currently unclear in elderly women, in patients at high cardiovascular risk and in those with structural heart disease on optimal treatment. Further studies are therefore needed to determine whether this highly effective therapy in breast cancer survival can be extended to such categories of patients.

Translated title of the contributionTrastuzumab-induced heart failure in the treatment of breast cancer
Original languageItalian
JournalGiornale Italiano di Cardiologia
Volume13
Issue number5 SUPPL. 1
DOIs
Publication statusPublished - May 2012

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Tarantini, L., Feola, M., Albini, A., Gori, S., Foglietta, J., Cicoira, M. A., & Pulignano, G. (2012). Lo scompenso cardiaco da trastuzumab nel trattamento del tumore al seno. Giornale Italiano di Cardiologia, 13(5 SUPPL. 1). https://doi.org/10.1714/1080.11830