Trattamento chirurgico del carcinoma epatocellulare in 140 pazienti cirrotici

G. Ferrari, R. Castoldi, E. Villa, G. L. Taccagni, E. Angeli, V. Di Carlo

Research output: Contribution to journalArticlepeer-review


A 10-year experience in surgical treatment of hepatocellular carcinoma (HCC) in 140 cirrhotic patients was reviewed in order to evaluate perioperative mortality, morbidity, survival rates and most reliable prognostic variables. Inclusion criteria were unifocal or bifocal lesions in child A or B patients. Six patients (4.2%) died in postoperative period and morbidity was 32.8 %. During follow-up 81 patients showed an HCC relapse and 59 died from the tumor. The 3- and 5-year actuarial survival excluding non-HCC related deaths was 55% and 37%. Similarly the 3- and 5-year disease-free survival was 29% and 20%. The analysis of prognostic variables for disease-free survival was significant only for presence of satellite nodules, microvascular infiltration and T for TNM classification. The authors conclude that HCC resection in cirrhotic patients can improve, in selected groups, long-term survival in comparison to natural history of the disease. Nevertheless only a small group of patients (20%) is disease-free at long-term.

Original languageEnglish
Pages (from-to)99-103
Number of pages5
Issue number2
Publication statusPublished - 1996


  • Hepatocellular carcinoma
  • Liver cirrhosis
  • Liver resection

ASJC Scopus subject areas

  • Surgery


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