Trauma and amyotrophic lateral sclerosis: a european population-based case-control study from the EURALS consortium

The EURALS Consortium

Research output: Contribution to journalArticle

Abstract

Objectives: To assess the association between amyotrophic lateral sclerosis (ALS) and previous traumatic events, age of trauma, and site of injury. Methods: A population-based case-control study was performed in five European countries (Italy, Ireland, France, United Kingdom, Serbia). Newly diagnosed ALS patients and matched controls were interviewed to collect relevant demographic factors and exposures. Key clinical features at diagnosis were collected in ALS patients. Trauma was any accidental event causing an injury. Injuries were dated and classified according to cause, severity, type, site, and complications. All exposures were censored five years before symptoms onset. Risks were computed as odds ratios (OR) with 95% confidence intervals (CI) using univariate and multivariate conditional logistic regression models. Results: Five hundred and seventy-five ALS patients and 1150 controls were interviewed. Disabling traumatic events predominated in the cases (OR 1.54 (95% CI 1.24–1.92)) and maintained significance after adjustment, with a significant gradient. A history of 2 + head injuries was associated with an almost three-fold increased risk of ALS. The risk was almost two-fold when trauma occurred at age 35–54 years. Site of injury was uneventful. Conclusions: Traumatic events leading to functional disability or confined to the head are risk factors for ALS. Traumatic events experienced at age 35–54 years carry the highest risk. © 2017 World Federation of Neurology on behalf of the Research Group on Motor Neuron Diseases
Original languageEnglish
Pages (from-to)118-125
Number of pages8
JournalAmyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Volume19
Issue number1-2
DOIs
Publication statusPublished - 2018

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Amyotrophic Lateral Sclerosis
Case-Control Studies
Wounds and Injuries
Population
Logistic Models
Odds Ratio
Confidence Intervals
Serbia
Motor Neuron Disease
Craniocerebral Trauma
Ireland
Italy
France
Head
Demography
Research

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Trauma and amyotrophic lateral sclerosis: a european population-based case-control study from the EURALS consortium. / The EURALS Consortium.

In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Vol. 19, No. 1-2, 2018, p. 118-125.

Research output: Contribution to journalArticle

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title = "Trauma and amyotrophic lateral sclerosis: a european population-based case-control study from the EURALS consortium",
abstract = "Objectives: To assess the association between amyotrophic lateral sclerosis (ALS) and previous traumatic events, age of trauma, and site of injury. Methods: A population-based case-control study was performed in five European countries (Italy, Ireland, France, United Kingdom, Serbia). Newly diagnosed ALS patients and matched controls were interviewed to collect relevant demographic factors and exposures. Key clinical features at diagnosis were collected in ALS patients. Trauma was any accidental event causing an injury. Injuries were dated and classified according to cause, severity, type, site, and complications. All exposures were censored five years before symptoms onset. Risks were computed as odds ratios (OR) with 95{\%} confidence intervals (CI) using univariate and multivariate conditional logistic regression models. Results: Five hundred and seventy-five ALS patients and 1150 controls were interviewed. Disabling traumatic events predominated in the cases (OR 1.54 (95{\%} CI 1.24–1.92)) and maintained significance after adjustment, with a significant gradient. A history of 2 + head injuries was associated with an almost three-fold increased risk of ALS. The risk was almost two-fold when trauma occurred at age 35–54 years. Site of injury was uneventful. Conclusions: Traumatic events leading to functional disability or confined to the head are risk factors for ALS. Traumatic events experienced at age 35–54 years carry the highest risk. {\circledC} 2017 World Federation of Neurology on behalf of the Research Group on Motor Neuron Diseases",
author = "{The EURALS Consortium} and E Pupillo and M Poloni and E Bianchi and Giorgia Giussani and Giancarlo Logroscino and S Zoccolella and A Chi{\`o} and Andrea Calvo and Massimo Corbo and C Lunetta and B Marin and D Mitchell and O Hardiman and J Rooney and Z Stevic and {Bandettini di Poggio}, M and M Filosto and MS Cotelli and M. Perini and N Riva and L Tremolizzo and E Vitelli and Danira Damiani and E Beghi",
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T1 - Trauma and amyotrophic lateral sclerosis: a european population-based case-control study from the EURALS consortium

AU - The EURALS Consortium

AU - Pupillo, E

AU - Poloni, M

AU - Bianchi, E

AU - Giussani, Giorgia

AU - Logroscino, Giancarlo

AU - Zoccolella, S

AU - Chiò, A

AU - Calvo, Andrea

AU - Corbo, Massimo

AU - Lunetta, C

AU - Marin, B

AU - Mitchell, D

AU - Hardiman, O

AU - Rooney, J

AU - Stevic, Z

AU - Bandettini di Poggio, M

AU - Filosto, M

AU - Cotelli, MS

AU - Perini, M.

AU - Riva, N

AU - Tremolizzo, L

AU - Vitelli, E

AU - Damiani, Danira

AU - Beghi, E

PY - 2018

Y1 - 2018

N2 - Objectives: To assess the association between amyotrophic lateral sclerosis (ALS) and previous traumatic events, age of trauma, and site of injury. Methods: A population-based case-control study was performed in five European countries (Italy, Ireland, France, United Kingdom, Serbia). Newly diagnosed ALS patients and matched controls were interviewed to collect relevant demographic factors and exposures. Key clinical features at diagnosis were collected in ALS patients. Trauma was any accidental event causing an injury. Injuries were dated and classified according to cause, severity, type, site, and complications. All exposures were censored five years before symptoms onset. Risks were computed as odds ratios (OR) with 95% confidence intervals (CI) using univariate and multivariate conditional logistic regression models. Results: Five hundred and seventy-five ALS patients and 1150 controls were interviewed. Disabling traumatic events predominated in the cases (OR 1.54 (95% CI 1.24–1.92)) and maintained significance after adjustment, with a significant gradient. A history of 2 + head injuries was associated with an almost three-fold increased risk of ALS. The risk was almost two-fold when trauma occurred at age 35–54 years. Site of injury was uneventful. Conclusions: Traumatic events leading to functional disability or confined to the head are risk factors for ALS. Traumatic events experienced at age 35–54 years carry the highest risk. © 2017 World Federation of Neurology on behalf of the Research Group on Motor Neuron Diseases

AB - Objectives: To assess the association between amyotrophic lateral sclerosis (ALS) and previous traumatic events, age of trauma, and site of injury. Methods: A population-based case-control study was performed in five European countries (Italy, Ireland, France, United Kingdom, Serbia). Newly diagnosed ALS patients and matched controls were interviewed to collect relevant demographic factors and exposures. Key clinical features at diagnosis were collected in ALS patients. Trauma was any accidental event causing an injury. Injuries were dated and classified according to cause, severity, type, site, and complications. All exposures were censored five years before symptoms onset. Risks were computed as odds ratios (OR) with 95% confidence intervals (CI) using univariate and multivariate conditional logistic regression models. Results: Five hundred and seventy-five ALS patients and 1150 controls were interviewed. Disabling traumatic events predominated in the cases (OR 1.54 (95% CI 1.24–1.92)) and maintained significance after adjustment, with a significant gradient. A history of 2 + head injuries was associated with an almost three-fold increased risk of ALS. The risk was almost two-fold when trauma occurred at age 35–54 years. Site of injury was uneventful. Conclusions: Traumatic events leading to functional disability or confined to the head are risk factors for ALS. Traumatic events experienced at age 35–54 years carry the highest risk. © 2017 World Federation of Neurology on behalf of the Research Group on Motor Neuron Diseases

U2 - 10.1080/21678421.2017.1386687

DO - 10.1080/21678421.2017.1386687

M3 - Article

VL - 19

SP - 118

EP - 125

JO - Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

JF - Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

SN - 2167-8421

IS - 1-2

ER -