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Traumatic experiences in childhood and adolescence: a meta-analysis of prospective studies assessing risk for psychosis : European Child and Adolescent Psychiatry. / Pastore, A.; de Girolamo, G.; Tafuri, S.; Tomasicchio, A.; Margari, F.In: Eur. Child Adolesc. Psychiatry, 24.06.2020.
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TY - JOUR
T1 - Traumatic experiences in childhood and adolescence: a meta-analysis of prospective studies assessing risk for psychosis
T2 - European Child and Adolescent Psychiatry
AU - Pastore, A.
AU - de Girolamo, G.
AU - Tafuri, S.
AU - Tomasicchio, A.
AU - Margari, F.
N1 - Export Date: 10 February 2021 CODEN: EAPSE Correspondence Address: Pastore, A.; Department of Basic Medical Sciences, Giulio Cesare Square, 11, Italy; email: firstname.lastname@example.org References: van Dam, D.S., van der Ven, E., Velthorst, E., Selten, J.P., Morgan, C., de Haan, L., Childhood bullying and the association with psychosis in non-clinical and clinical samples: a review and meta-analysis (2012) Psychol Med, 42, pp. 2463-2474. , PID: 22400714; Varese, F., Smeets, F., Drukker, M., Lieverse, R., Lataster, T., Viechtbauer, W., Read, J., Bentall, R.P., Childhood adversities increase the risk of psychosis: a meta-analysis of patient-control, prospective- and cross-sectional cohort studies (2012) Schizophr Bull, 38, pp. 661-671. , PID: 22461484; Abajobir, A.A., Kisely, S., Scott, J.G., Williams, G., Clavarino, A., Strathearn, L., Najman, J.M., Childhood maltreatment and young adulthood hallucinations, delusional experiences, and psychosis: a longitudinal study (2017) Schizophr Bull, 43, pp. 1045-1055. , PID: 28338760; Arseneault, L., Cannon, M., Fisher, H.L., Polanczyk, G., Moffitt, T.E., Caspi, A., Childhood trauma and children’s emerging psychotic symptoms: a genetically sensitive longitudinal cohort study (2011) Am J Psychiatry, 168, pp. 65-72. , PID: 20952460; De Loore, E., Drukker, M., Gunther, N., Feron, F., Deboutte, D., Sabbe, B., Mengelers, R., Myin-Germeys, I., Childhood negative experiences and subclinical psychosis in adolescence: a longitudinal general population study (2007) Early Interv Psychiatry, 1, pp. 201-207; Andersen, S.L., Tomada, A., Vincow, E.S., Valente, E., Polcari, A., Teicher, M.H., Preliminary evidence for sensitive periods in the effect of childhood sexual abuse on regional brain development (2008) J Neuropsychiatry Clin Neurosci, 20, pp. 292-301. , PID: 18806232; Read, J., van Os, J., Morrison, A.P., Ross, C.A., Childhood trauma, psychosis and schizophrenia: a literature review with theoretical and clinical implications (2005) Acta Psychiatr Scand, 112, pp. 330-350. , COI: 1:STN:280:DC%2BD2Mrkslantg%3D%3D, PID: 16223421; Green, J.G., McLaughlin, K.A., Berglund, P.A., Gruber, M.J., Sampson, N.A., Zaslavsky, A.M., Kessler, R.C., Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication I associations with first onset of DSM-IV disorders (2010) Arch Gen Psychiatry, 67, pp. 113-123. , PID: 20124111; Husted, J.A., Ahmed, R., Chow, E.W.C., Brzustowicz, L.M., Bassett, A.S., Childhood trauma and genetic factors in familial schizophrenia associated with the NOS1AP gene (2010) Schizophr Res, 121, pp. 187-192. , PID: 20541371; Reduced cortical thickness as an outcome of differential sensitivity to environmental risks in schizophrenia (2011) Biol Psychiatry, 69, pp. 487-494; Schreier, A., Wolke, D., Thomas, K., Horwood, J., Hollis, C., Gunnell, D., Lewis, G., Harrison, G., Prospective study of peer victimization in childhood and psychotic symptoms in a nonclinical population at age 12 years (2009) Arch Gen Psychiatry, 66, pp. 527-536. , PID: 19414712; Lardinois, M., Lataster, T., Mengelers, R., Van Os, J., Myin-Germeys, I., Childhood trauma and increased stress sensitivity in psychosis (2011) Acta Psychiatr Scand, 123, pp. 28-35. , COI: 1:STN:280:DC%2BC3M%2FitlCjuw%3D%3D, PID: 20712824; Janssen, I., Krabbendam, L., Bak, M., Hanssen, M., Vollebergh, W., de Graaf, R., van Os, J., Childhood abuse as a risk factor for psychotic experiences (2004) Acta Psychiatr Scand, 109, pp. 38-45. , COI: 1:STN:280:DC%2BD2c%2Fms1GnsA%3D%3D, PID: 14674957; Shevlin, M., Houston, J.E., Dorahy, M.J., Adamson, G., Cumulative traumas and psychosis: an analysis of the national comorbidity survey and the British Psychiatric Morbidity Survey (2008) Schizophr Bull, 34, pp. 193-199. , PID: 17586579; Pfeifer, S., Krabbendam, L., Myin-Germeys, I., Derom, C., Wichers, M., Jacobs, N., Thiery, E.W., van Os, J., A cognitive intermediate phenotype study confirming possible gene-early adversity interaction in psychosis outcome: a general population twin study (2010) Psychosis, 2, pp. 1-11; Wahlberg, K.E., Lynne, L.C., Oja, H., Keskitalo, P., Pykalainen, L., Lahti, I., Moring, J., Tienari, P., Gene-environment interaction in vulnerability to schizophrenia: findings from the Finnish adoptive family study of schizophrenia (1997) Am J Psychiatry, 154, pp. 355-362. , COI: 1:STN:280:DyaK2s3gslCqsg%3D%3D, PID: 9054783; Wicks, S., Hjern, A., Dalman, C., Social risk or genetic liability for psychosis? A study of children born in sweden and reared by adoptive parents (2010) Am J Psychiatry, 167, pp. 1240-1246. , PID: 20686186; Bechdolf, A., Thompson, A., Nelson, B., Cotton, S., Simmons, M.B., Amminger, G.P., Leicester, S., Yung, A.R., Experience of trauma and conversion to psychosis in an ultra-high-risk (prodromal) group (2010) Acta Psychiatr Scand, 121, pp. 377-384. , COI: 1:STN:280:DC%2BC3cvhtl2mtA%3D%3D, PID: 20199494; Wigman, J.T., van Winkel, R., Ormel, J., Verhulst, F.C., van Os, J., Vollebergh, W.A., Early trauma and familial risk in the development of the extended psychosis phenotype in adolescence (2012) Acta Psychiatr Scand, 126, pp. 266-273. , COI: 1:STN:280:DC%2BC38rjtl2nuw%3D%3D, PID: 22486536; Roberts, B.W., DelVecchio, W.F., The rank-order consistency of personality traits from childhood to old age: a quantitative review of longitudinal studies (2000) Psychol Bull, 26, pp. 3-25; Benedict, R.H.B., Zgaljardic, D.J., Practice effects during repeated administrations of memory tests with and without alternate forms (1998) J Clin Exp Neuropsyc., 20, pp. 339-352. , COI: 1:STN:280:DyaK1M%2FlvFaqtg%3D%3D; Fergusson, M., (1999) Childhood sexual abuse. An evidence based perspective, , Sage Publications Inc, Thousand Oaks; Gilbert, R., Widom, C.S., Browne, K., Fergusson, D., Webb, E., Janson, S., Burden and consequences of child maltreatment in high-income countries (2009) Lancet, 373, pp. 68-81. , PID: 19056114; Bendall, S., Jackson, H.J., Hulbert, C.A., McGorry, P.D., Childhood trauma and psychotic disorders: a systematic, critical review of the evidence (2008) Schizophr Bull, 34, pp. 568-579. , PID: 18003630; Alvarez-Jimenez, M., Gleeson, J.F., Henry, L.P., Harrigan, S.M., Harris, M.G., Amminger, G.P., Killackey, E., McGorry, P.D., Prediction of a single psychotic episode: a 7.5-year, prospective study in first-episode psychosis (2011) Schizophr Res, 125, pp. 236-246. , COI: 1:STN:280:DC%2BC3M7lt1ShtA%3D%3D, PID: 21081266; Edwards, V.J., Holden, G.W., Felitti, V.J., Anda, R.F., Relationship between multiple forms of childhood maltreatment and adult mental health in community respondents: results from the adverse childhood experiences study (2003) Am J Psychiatry, 160, pp. 1453-1460. , PID: 12900308; Lau, A.S., Leeb, R.T., English, D., Graham, J.C., Briggs, E.C., Brody, K.E., Marshall, J.M., What’s in a name? A com- parison of methods for classifying predominant type of mal-treatment (2005) Child Abuse Negl, 29, pp. 533-551. , PID: 15970324; Wolke, D., Lereya, S.T., Fisher, H.L., Lewis, G., Zammit, S., Bullying in elementary school and psychotic experiences at 18 years: a longitudinal, population-based cohort study (2014) Psychol Med, 44, pp. 2199-2211. , COI: 1:STN:280:DC%2BC2c3ms1KgtQ%3D%3D, PID: 24342773; Galletly, C., Van Hooff, M., McFarlane, A., Psychotic symptoms in young adults exposed to childhood trauma—a 20 year follow-up study (2011) Schizophr Res, 127, pp. 76-82. , PID: 21256719; Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement (2009) Ann Intern Med, 151 (4), pp. 264-269; Hedges, L.V., Vevea, J.L., Fixed- and random-effects models in meta-analysis (1998) Psychol Methods, 3, pp. 486-504; Higgins, J.P., Thompson, S.G., Deeks, J.J., Altman, D.G., Measuring inconsistency in meta-analyses (2003) BMJ, 327, pp. 557-560. , PID: 192859; Wells, G.A., Shea, B., O’Connell, D., (2019) The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in metaanalyses., , .(http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp), Ottawa Hospital Research Institute, Ottawa, Accessed 14 Jun 2019; Crocetti, Systematic reviews with meta-analysis: why, when, and how? (2016) Emerg Adulthood, 4, pp. 3-18; Rothstein, (2005) Publication bias in meta-analysis: prevention, assessment and adjustments, , Wiley, Chichester; Egger, M., Davey Smith, G., Schneider, M., Minder, C., Bias in meta-analysis detected by a simple, graphical test (1997) BMJ, 315, pp. 629-634. , COI: 1:STN:280:DyaK2svls1KjtA%3D%3D, PID: 2127453; Begg, C.B., Mazumdar, M., Operating characteristics of a rank correlation test for publication bias (1994) Biometrics, 50, pp. 1088-1101. , COI: 1:STN:280:DyaK2Mzgs1GrtQ%3D%3D; Duval, S., Tweedie, R., Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis (2000) Biometrics, 56, pp. 455-463. , COI: 1:STN:280:DC%2BD3cvotVylsA%3D%3D, PID: 10877304; Cutajar, M.C., Mullen, P.E., Ogloff, J.R., Thomas, S.D., Wells, D.L., Spataro, J., Psychopathology in a large cohort of sexually abused children followed up to 43 years (2010) Child Abuse Negl, 34, pp. 813-822. , PID: 20888636; Elklit, A., Shevlin, M., Female sexual victimization predicts psychosis: a case-control study based on the Danish Registry System (2011) Schizophr Bull, 37, pp. 1305-1310. , PID: 20488881; Kelleher, I., Keeley, H., Corcoran, P., Ramsay, H., Wasserman, C., Carli, V., Sarchiapone, M., Cannon, M., Childhood trauma and psychosis in a prospective cohort study: cause, effect, and directionality (2013) Am J Psychiatry, 170, pp. 734-741. , PID: 23599019; Lataster, J., Myin-Germeys, I., Lieb, R., Wittchen, H.U., van Os, J., Adversity and psychosis: a 10-year prospective study investigating synergism between early and recent adversity in psychosis (2012) Acta Psychiatr Scand, 125, pp. 388-399. , COI: 1:STN:280:DC%2BC38zotF2gsQ%3D%3D, PID: 22128839; Spauwen, J., Krabbendam, L., Lieb, R., Wittchen, H.U., van Os, J., Impact of psychological trauma on the development of psychotic symptoms: relationship with psychosis proneness (2006) Br J Psychiatry, 188, pp. 527-533. , PID: 16738342; Fisher, H.L., Schreier, A., Zammit, S., Maughan, B., Munafo, M.R., Lewis, G., Wolke, D., Pathways between childhood victimization and psychosis-like symptoms in the ALSPAC birth cohort (2013) Schizophr Bull, 39, pp. 1045-1055. , PID: 22941743; van der Ven, E., Dalman, C., Wicks, S., Allebeck, P., Magnusson, C., van Os, J., Selten, J.P., Testing Odegaard’s selective migration hypothesis: a longitudinal cohort study of risk factors for non-affective psychotic disorders among prospective emigrants (2015) Psychol Med, 45, pp. 727-734. , PID: 25084213; van Nierop, M., Janssens, M., OoPI, G.R., Bruggeman, R., Cahn, W., de Haan, L., Kahn, R.S., Wiersma, D., Evidence that transition from health to psychotic disorder can be traced to semi-ubiquitous environmental effects operating against background genetic risk (2013) PLoS One, 8. , PID: 24223116; Konings, M., Stefanis, N., Kuepper, R., de Graaf, R., ten Have, M., van Os, J., Bakoula, C., Henquet, C., Replication in two independent population-based samples that childhood maltreatment and cannabis use synergistically impact on psychosis risk (2012) Psychol Med, 42, pp. 149-159. , COI: 1:STN:280:DC%2BC38%2FivFCmtQ%3D%3D, PID: 21676285; Kramer, I.M., Simons, C.J., Myin-Germeys, I., Jacobs, N., Derom, C., Thiery, E., van Os, J., Wichers, M., Evidence that genes for depression impact on the pathway from trauma to psychotic-like symptoms by occasioning emotional dysregulation (2012) Psychol Med, 42, pp. 283-294. , COI: 1:STN:280:DC%2BC38zlt1Kmug%3D%3D, PID: 21835094; Kuepper, R., van Os, J., Lieb, R., Wittchen, H.U., Henquet, C., Do cannabis and urbanicity co-participate in causing psychosis? Evidence from a 10-year follow-up cohort study (2011) Psychol Med, 41, pp. 2121-2129. , COI: 1:STN:280:DC%2BC3Mjos1OgtA%3D%3D, PID: 21466750; Lee, W.E., Kwok, C.H., Hunter, E.C., Richards, M., David, A.S., Prevalence and childhood antecedents of depersonalization syndrome in a UK birth cohort (2012) Soc Psychiatry Psychiatr Epidemiol, 47, pp. 253-261. , PID: 21181112; Makikyro, T., Sauvola, A., Moring, J., Veijola, J., Nieminen, P., Jarvelin, M.R., Isohanni, M., Hospital-treated psychiatric disorders in adults with a single-parent and two-parent family background: a 28-year follow-up of the 1966 Northern Finland Birth Cohort (1998) Fam Process, 37, pp. 335-344. , COI: 1:STN:280:DyaK1M%2FpsFSmsQ%3D%3D, PID: 9879003; Laursen, T.M., Munk-Olsen, T., Nordentoft, M., Bo Mortensen, P., A comparison of selected risk factors for unipolar depressive disorder, bipolar affective disorder, schizoaffective disorder, and schizophrenia from a danish population-based cohort (2007) J Clin Psychiatry, 68, pp. 1673-1681. , PID: 18052560; Boden, J.M., van Stockum, S., Horwood, L.J., Fergusson, D.M., Bullying victimization in adolescence and psychotic symptomatology in adulthood: evidence from a 35-year study (2016) Psychol Med, 46, pp. 1311-1320. , COI: 1:STN:280:DC%2BC28njs1yrsg%3D%3D, PID: 26804185; Catone, G., Marwaha, S., Kuipers, E., Lennox, B., Freeman, D., Bebbington, P., Broome, M., Bullying victimisation and risk of psychotic phenomena: analyses of British national survey data (2015) Lancet Psychiatry, 2, pp. 618-624. , PID: 26303559; Shakoor, S., McGuire, P., Cardno, A., Freeman, D., Plomin, R., Ronald, A., A shared genetic propensity underlies experiences of bullying victimization in late childhood and self-rated paranoid thinking in adolescence (2015) Schizophr Bull, 41, pp. 754-763. , PID: 25323579; Croft, J., Heron, J., Teufel, C., Cannon, M., Wolke, D., Thompson, A., Houtepen, L., Zammit, S., Association of trauma type, age of exposure, and frequency in childhood and adolescence with psychotic experiences in early adulthood (2018) JAMA Psychiatry, 76, pp. 79-86; McGrath, J.J., McLaughlin, K.A., Saha, S., The association between childhood adversities and subsequent first onset of psychotic experiences: a cross-national analysis of 23 998 respondents from 17 countries (2017) Psychol Med, 47 (7), pp. 1230-1245. , COI: 1:STN:280:DC%2BC1c7jsFaiug%3D%3D, PID: 28065209; Crush, E., Arseneault, L., Jaffee, S.R., Danese, A., Fisher, H.L., Protective factors for psychotic symptoms among poly-victimized children (2018) Schizophr Bul, 44 (3), pp. 691-700; Zubin, J., Spring, B., Vulnerability–a new view of schizophrenia (1977) J Abnorm Psychol, 86, pp. 103-126. , COI: 1:STN:280:DyaE2s7msF2rsA%3D%3D, PID: 858828; Lim, C., Chong, S.A., Keefe, R., Psychosocial factors in the neurobiology of schizophrenia: a selective review (2009) Ann Acad Med Singapore, 38, pp. 402-406. , PID: 19521639; Spataro, J., Mullen, P.E., Burgess, P.M., Wells, D.L., Moss, S.A., Impact of child sexual abuse on mental health: prospective study in males and females (2004) Br J Psychiatry, 184, pp. 416-421. , PID: 15123505; Kendler, K.S., Kessler, R.C., Walters, E.E., Maclean, C., Neale, M.C., Heath, A.C., Eaves, L.J., Stressful life events, genetic liability, and onset of an episode of major depression in women (1995) Am J Psychiatry, 152, pp. 833-842. , COI: 1:STN:280:DyaK2M3nsVOntA%3D%3D, PID: 7755111; Kendler, K.S., KarkowskiShuman, L., Stressful life events and genetic liability to major depression: genetic control of exposure to the environment (1997) Psychol Med, 27, pp. 539-547. , COI: 1:STN:280:DyaK2s3pvVahtQ%3D%3D, PID: 9153675; Wohlwill, J.F., (1973) The study of behavioral development, , Academic, New York; Dantchev, S., Zammit, S., Wolke, D., Sibling bullying in middle childhood and psychotic disorder at 18 years: a prospective cohort study (2018) Psychol Med, 48, pp. 2321-2328. , PID: 29429415
PY - 2020/6/24
Y1 - 2020/6/24
N2 - Evidence of the association between traumatic experiences and psychosis are uncertain with respect to temporal order, clinical outcomes and the role of the age and genetic liability. The aim of the present meta-analysis was to explore the temporal relationship between the development of psychosis and traumatic exposure using prospective studies and to examine the role of moderation factors on overall effect sizes. Studies were identified by searching Embase-Ovid, PsycINFO (EBSCO), Pubmed, Scopus, Web of Science databases, and yielded an initial total of 9016 papers, leaving finally 23 after the screening process. Three sets of meta-analyses estimated the risk of developing psychotic experiences or full clinical psychosis by having experienced maltreatment by an adult or bullying by peers or parental death, using the random-effects model. Bullying by peers (OR = 2.28 [1.64, 4.34]), maltreatment by an adult (OR = 2.20 [1.72, 2.81]) and parental death (OR = 1.24 [1.06, 1.44]) all increased the risk of psychosis. Moderator analysis showed that negative effects of bullying were detected especially in those with genetic liability for psychosis and exposure to multiple trauma types; studies with higher prevalence of males showed a stronger risk for those exposed to parental death. No significant meta-regression was found between the risk of developing a full clinical psychosis or a psychotic experience. Lack of studies hampered the results about the age of trauma occurrence. The cumulative effect of being bullied from peers and experiencing other adversities during childhood and/or adolescence, together with genetic liability for psychosis, appears to confer the highest risk for developing psychotic symptoms later in life. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
AB - Evidence of the association between traumatic experiences and psychosis are uncertain with respect to temporal order, clinical outcomes and the role of the age and genetic liability. The aim of the present meta-analysis was to explore the temporal relationship between the development of psychosis and traumatic exposure using prospective studies and to examine the role of moderation factors on overall effect sizes. Studies were identified by searching Embase-Ovid, PsycINFO (EBSCO), Pubmed, Scopus, Web of Science databases, and yielded an initial total of 9016 papers, leaving finally 23 after the screening process. Three sets of meta-analyses estimated the risk of developing psychotic experiences or full clinical psychosis by having experienced maltreatment by an adult or bullying by peers or parental death, using the random-effects model. Bullying by peers (OR = 2.28 [1.64, 4.34]), maltreatment by an adult (OR = 2.20 [1.72, 2.81]) and parental death (OR = 1.24 [1.06, 1.44]) all increased the risk of psychosis. Moderator analysis showed that negative effects of bullying were detected especially in those with genetic liability for psychosis and exposure to multiple trauma types; studies with higher prevalence of males showed a stronger risk for those exposed to parental death. No significant meta-regression was found between the risk of developing a full clinical psychosis or a psychotic experience. Lack of studies hampered the results about the age of trauma occurrence. The cumulative effect of being bullied from peers and experiencing other adversities during childhood and/or adolescence, together with genetic liability for psychosis, appears to confer the highest risk for developing psychotic symptoms later in life. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
KW - Bullying
KW - Longitudinal studies
KW - Maltreatment
KW - Parental death
KW - Psychosis
KW - Trauma
U2 - 10.1007/s00787-020-01574-9
DO - 10.1007/s00787-020-01574-9
M3 - Article
JO - Eur. Child Adolesc. Psychiatry
JF - Eur. Child Adolesc. Psychiatry
SN - 1018-8827