Trazodone for deafferentation pain. Comparison with amitriptyline

V. Ventafridda, A. Caraceni, L. Saita, C. Bonezzi, F. De Conno, G. Guarise, G. Ramella, V. Silvani, M. Tamburini, F. Toscani

Research output: Contribution to journalArticle

Abstract

We report a clinical multicentre experience with antidepressant agents (trazodone and amitriptyline) in the treatment of chronic pain due to deafferentation. Forty five patients were admitted to the study; most of them with oncological peripheral nerve lesions. Almost all of them were already being treated with NSAID in association with weak or strong opioids. A random double blind study was performed: 23 patients were treated with trazodone, 22 with amitryptiline. In the assessment of results, pain intensity, hours of sleep, hours standing and lying, side effects, mood, anxiety and weakness were all taken into consideration. The therapeutic analgesic efficacy of the two drugs proved to be similar.

Original languageEnglish
JournalPsychopharmacology
Volume95
Issue number1
DOIs
Publication statusPublished - Mar 1988

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Trazodone
Amitriptyline
Non-Steroidal Anti-Inflammatory Agents
Pain Measurement
Peripheral Nerves
Double-Blind Method
Chronic Pain
Opioid Analgesics
Antidepressive Agents
Analgesics
Sleep
Anxiety
Therapeutics
Pharmaceutical Preparations

Keywords

  • Amitriptyline
  • Cancer
  • Deafferentation pain
  • Trazodone

ASJC Scopus subject areas

  • Pharmacology

Cite this

Trazodone for deafferentation pain. Comparison with amitriptyline. / Ventafridda, V.; Caraceni, A.; Saita, L.; Bonezzi, C.; De Conno, F.; Guarise, G.; Ramella, G.; Silvani, V.; Tamburini, M.; Toscani, F.

In: Psychopharmacology, Vol. 95, No. 1, 03.1988.

Research output: Contribution to journalArticle

Ventafridda, V, Caraceni, A, Saita, L, Bonezzi, C, De Conno, F, Guarise, G, Ramella, G, Silvani, V, Tamburini, M & Toscani, F 1988, 'Trazodone for deafferentation pain. Comparison with amitriptyline', Psychopharmacology, vol. 95, no. 1. https://doi.org/10.1007/BF00172630
Ventafridda, V. ; Caraceni, A. ; Saita, L. ; Bonezzi, C. ; De Conno, F. ; Guarise, G. ; Ramella, G. ; Silvani, V. ; Tamburini, M. ; Toscani, F. / Trazodone for deafferentation pain. Comparison with amitriptyline. In: Psychopharmacology. 1988 ; Vol. 95, No. 1.
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