Trazodone for deafferentation pain. Comparison with amitriptyline

V. Ventafridda; A. Caraceni; L. Saita; C. Bonezzi; F. De Conno; G. Guarise; G. Ramella; V. Silvani; M. Tamburini; F. Toscani

doi:10.1007/BF00172630

Trazodone for deafferentation pain. Comparison with amitriptyline

V. Ventafridda, A. Caraceni, L. Saita, C. Bonezzi, F. De Conno, G. Guarise, G. Ramella, V. Silvani, M. Tamburini, F. Toscani

Research output: Contribution to journal › Article › peer-review

Abstract

We report a clinical multicentre experience with antidepressant agents (trazodone and amitriptyline) in the treatment of chronic pain due to deafferentation. Forty five patients were admitted to the study; most of them with oncological peripheral nerve lesions. Almost all of them were already being treated with NSAID in association with weak or strong opioids. A random double blind study was performed: 23 patients were treated with trazodone, 22 with amitryptiline. In the assessment of results, pain intensity, hours of sleep, hours standing and lying, side effects, mood, anxiety and weakness were all taken into consideration. The therapeutic analgesic efficacy of the two drugs proved to be similar.

Original language	English
Journal	Psychopharmacology
Volume	95
Issue number	1
DOIs	https://doi.org/10.1007/BF00172630
Publication status	Published - Mar 1988

Keywords

Amitriptyline
Cancer
Deafferentation pain
Trazodone

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1007/BF00172630

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title = "Trazodone for deafferentation pain. Comparison with amitriptyline",

abstract = "We report a clinical multicentre experience with antidepressant agents (trazodone and amitriptyline) in the treatment of chronic pain due to deafferentation. Forty five patients were admitted to the study; most of them with oncological peripheral nerve lesions. Almost all of them were already being treated with NSAID in association with weak or strong opioids. A random double blind study was performed: 23 patients were treated with trazodone, 22 with amitryptiline. In the assessment of results, pain intensity, hours of sleep, hours standing and lying, side effects, mood, anxiety and weakness were all taken into consideration. The therapeutic analgesic efficacy of the two drugs proved to be similar.",

keywords = "Amitriptyline, Cancer, Deafferentation pain, Trazodone",

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AU - Ventafridda, V.

AU - Caraceni, A.

AU - Saita, L.

AU - Bonezzi, C.

AU - De Conno, F.

AU - Guarise, G.

AU - Ramella, G.

AU - Silvani, V.

AU - Tamburini, M.

AU - Toscani, F.

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AB - We report a clinical multicentre experience with antidepressant agents (trazodone and amitriptyline) in the treatment of chronic pain due to deafferentation. Forty five patients were admitted to the study; most of them with oncological peripheral nerve lesions. Almost all of them were already being treated with NSAID in association with weak or strong opioids. A random double blind study was performed: 23 patients were treated with trazodone, 22 with amitryptiline. In the assessment of results, pain intensity, hours of sleep, hours standing and lying, side effects, mood, anxiety and weakness were all taken into consideration. The therapeutic analgesic efficacy of the two drugs proved to be similar.

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