Abstract
We report a clinical multicentre experience with antidepressant agents (trazodone and amitriptyline) in the treatment of chronic pain due to deafferentation. Forty five patients were admitted to the study; most of them with oncological peripheral nerve lesions. Almost all of them were already being treated with NSAID in association with weak or strong opioids. A random double blind study was performed: 23 patients were treated with trazodone, 22 with amitryptiline. In the assessment of results, pain intensity, hours of sleep, hours standing and lying, side effects, mood, anxiety and weakness were all taken into consideration. The therapeutic analgesic efficacy of the two drugs proved to be similar.
| Original language | English |
|---|---|
| Journal | Psychopharmacology |
| Volume | 95 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Mar 1988 |
Fingerprint
Keywords
- Amitriptyline
- Cancer
- Deafferentation pain
- Trazodone
ASJC Scopus subject areas
- Pharmacology
Cite this
Trazodone for deafferentation pain. Comparison with amitriptyline. / Ventafridda, V.; Caraceni, A.; Saita, L.; Bonezzi, C.; De Conno, F.; Guarise, G.; Ramella, G.; Silvani, V.; Tamburini, M.; Toscani, F.
In: Psychopharmacology, Vol. 95, No. 1, 03.1988.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Trazodone for deafferentation pain. Comparison with amitriptyline
AU - Ventafridda, V.
AU - Caraceni, A.
AU - Saita, L.
AU - Bonezzi, C.
AU - De Conno, F.
AU - Guarise, G.
AU - Ramella, G.
AU - Silvani, V.
AU - Tamburini, M.
AU - Toscani, F.
PY - 1988/3
Y1 - 1988/3
N2 - We report a clinical multicentre experience with antidepressant agents (trazodone and amitriptyline) in the treatment of chronic pain due to deafferentation. Forty five patients were admitted to the study; most of them with oncological peripheral nerve lesions. Almost all of them were already being treated with NSAID in association with weak or strong opioids. A random double blind study was performed: 23 patients were treated with trazodone, 22 with amitryptiline. In the assessment of results, pain intensity, hours of sleep, hours standing and lying, side effects, mood, anxiety and weakness were all taken into consideration. The therapeutic analgesic efficacy of the two drugs proved to be similar.
AB - We report a clinical multicentre experience with antidepressant agents (trazodone and amitriptyline) in the treatment of chronic pain due to deafferentation. Forty five patients were admitted to the study; most of them with oncological peripheral nerve lesions. Almost all of them were already being treated with NSAID in association with weak or strong opioids. A random double blind study was performed: 23 patients were treated with trazodone, 22 with amitryptiline. In the assessment of results, pain intensity, hours of sleep, hours standing and lying, side effects, mood, anxiety and weakness were all taken into consideration. The therapeutic analgesic efficacy of the two drugs proved to be similar.
KW - Amitriptyline
KW - Cancer
KW - Deafferentation pain
KW - Trazodone
UR - http://www.scopus.com/inward/record.url?scp=0023889741&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023889741&partnerID=8YFLogxK
U2 - 10.1007/BF00172630
DO - 10.1007/BF00172630
M3 - Article
C2 - 3133714
AN - SCOPUS:0023889741
VL - 95
JO - Psychopharmacology
JF - Psychopharmacology
SN - 0033-3158
IS - 1
ER -