Trazodone for deafferentation pain. Comparison with amitriptyline

V. Ventafridda, A. Caraceni, L. Saita, C. Bonezzi, F. De Conno, G. Guarise, G. Ramella, V. Silvani, M. Tamburini, F. Toscani

Research output: Contribution to journalArticlepeer-review


We report a clinical multicentre experience with antidepressant agents (trazodone and amitriptyline) in the treatment of chronic pain due to deafferentation. Forty five patients were admitted to the study; most of them with oncological peripheral nerve lesions. Almost all of them were already being treated with NSAID in association with weak or strong opioids. A random double blind study was performed: 23 patients were treated with trazodone, 22 with amitryptiline. In the assessment of results, pain intensity, hours of sleep, hours standing and lying, side effects, mood, anxiety and weakness were all taken into consideration. The therapeutic analgesic efficacy of the two drugs proved to be similar.

Original languageEnglish
Issue number1
Publication statusPublished - Mar 1988


  • Amitriptyline
  • Cancer
  • Deafferentation pain
  • Trazodone

ASJC Scopus subject areas

  • Pharmacology


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