Treating iron overload in patients with non-transfusion-dependent thalassemia

Ali T. Taher, Vip Viprakasit, Khaled M. Musallam, M. Domenica Cappellini

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Despite receiving no or only occasional blood transfusions, patients with non-transfusion-dependent thalassemia (NTDT) have increased intestinal iron absorption and can accumulate iron to levels comparable with transfusion-dependent patients. This iron accumulation occurs more slowly in NTDT patients compared to transfusion-dependent thalassemia patients, and complications do not arise until later in life. It remains crucial for these patients' health to monitor and appropriately treat their iron burden. Based on recent data, including a randomized clinical trial on iron chelation in NTDT, a simple iron chelation treatment algorithm is presented to assist physicians with monitoring iron burden and initiating chelation therapy in this group of patients.

Original languageEnglish
Pages (from-to)409-415
Number of pages7
JournalAmerican Journal of Hematology
Volume88
Issue number5
DOIs
Publication statusPublished - May 2013

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Iron Overload
Thalassemia
Iron
Chelation Therapy
Intestinal Absorption
Blood Transfusion
Randomized Controlled Trials
Physicians
Health

ASJC Scopus subject areas

  • Hematology

Cite this

Treating iron overload in patients with non-transfusion-dependent thalassemia. / Taher, Ali T.; Viprakasit, Vip; Musallam, Khaled M.; Cappellini, M. Domenica.

In: American Journal of Hematology, Vol. 88, No. 5, 05.2013, p. 409-415.

Research output: Contribution to journalArticle

Taher, Ali T. ; Viprakasit, Vip ; Musallam, Khaled M. ; Cappellini, M. Domenica. / Treating iron overload in patients with non-transfusion-dependent thalassemia. In: American Journal of Hematology. 2013 ; Vol. 88, No. 5. pp. 409-415.
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