Treating progressive multifocal leukoencephalopathy with interleukin 7 and vaccination with JC virus capsid protein VP1

Mireia Sospedra, Sven Schippling, Sara Yousef, Ilijas Jelcic, Silvia Bofill-Mas, Raquel Planas, Jan Patrick Stellmann, Viktoria Demina, Paola Cinque, Robert Garcea, Therese Croughs, Rosina Girones, Roland Martin

Research output: Contribution to journalArticlepeer-review

Abstract

Progressive multifocal leukoencephalopathy is a currently untreatable infection of the brain. Here, we demonstrate in 2 patients that treatment with interleukin 7, JC polyomavirus (JCV) capsid protein VP1, and a Toll-like receptor 7 agonist used as adjuvant, was well tolerated, and showed a very favorable safety profile and unexpected efficacy that warrant further investigation.

Original languageEnglish
Pages (from-to)1588-1592
Number of pages5
JournalClinical Infectious Diseases
Volume59
Issue number11
DOIs
Publication statusPublished - Dec 1 2014

Keywords

  • IL-7
  • JC virus
  • Progressive multifocal leukoencephalopathy
  • VP1

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)

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