Treating psoriasis with etanercept in Italian clinical practice: Prescribing practices and duration of remission following discontinuation

Annalisa Arcese, Nicola Aste, Alberta Bettacchi, Germana Camplone, Franca Cantoresi, Marzia Caproni, Domenico Damico, Paolo Fabbri, Giorgio Filosa, Antonia Galluccio, Katharina Hansel, Paolo Lisi, Giuseppe Micali, Maria Letizia Musumeci, Massimiliano Nicolini, Aurora Parodi, Mario Patania, Michele Pezza, Concetta Potenza, Antonio RichettaMarco Simonacci, Piergiusto Trevisan, Giancarlo Valenti, Stefano Calvieri

Research output: Contribution to journalArticle

Abstract

Background: Conventional antipsoriatic therapies are often administered until remission, with treatment resumed in the case of relapse, in order to reduce the likelihood of cumulative, dose-dependent toxicities. Biological agents have been safely used in continuous therapy. Objective: To assess the use of etanercept for psoriasis in clinical practice in Italy. Methods: This was an observational study carried out in 13 dermatological centres across Italy in patients with plaque psoriasis (with a Psoriasis Area and Severity Index [PASI] score ≥10) treated with etanercept. The study comprised a treatment and subsequent discontinuation period. Patients were eligible if they had plaque psoriasis and had begun treatment with etanercept between 1 September 2007 and 1 April 2008. Patients were evaluable for the duration of discontinuation analysis if they achieved a PASI reduction ≥50% (PASI50) and a PASI score

Original languageEnglish
Pages (from-to)507-516
Number of pages10
JournalClinical Drug Investigation
Volume30
Issue number8
DOIs
Publication statusPublished - 2010

Keywords

  • Etanercept, therapeutic use
  • Psoriasis, treatment

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Medicine(all)

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    Arcese, A., Aste, N., Bettacchi, A., Camplone, G., Cantoresi, F., Caproni, M., Damico, D., Fabbri, P., Filosa, G., Galluccio, A., Hansel, K., Lisi, P., Micali, G., Musumeci, M. L., Nicolini, M., Parodi, A., Patania, M., Pezza, M., Potenza, C., ... Calvieri, S. (2010). Treating psoriasis with etanercept in Italian clinical practice: Prescribing practices and duration of remission following discontinuation. Clinical Drug Investigation, 30(8), 507-516. https://doi.org/10.2165/11537470-000000000-00000