Treatment and outcome of advanced external auditory canal and middle ear squamous cell carcinoma

Giovanni Cristalli, Valentina Manciocco, Barbara Pichi, Laura Marucci, Giorgio Arcangeli, Stefano Telera, Giuseppe Spriano

Research output: Contribution to journalArticle

Abstract

This is a retrospective study to evaluate the outcomes and complications of combined treatment, surgery with or without adjunctive intraoperative radiotherapy, of locally advanced temporal bone squamous cell carcinoma. A series of 17 patients with locally advanced squamous cell carcinoma of the temporal bone were treated between September 2002 and February 2007. Eleven patients had primary tumors, and 6 patients had recurrences. According to the University of Pittsburgh staging system, 5 patients were stage II (T2 N0), 6 patients were stage III (5, T3 N0 and 1, T1 N1), and 6 patients were stage IV (5, T3 N2b and 1, T4 N0). All patients underwent lateral temporal bone resection and pedicle flap reconstruction. Eight patients received intraoperative and postoperative radiotherapies, 4 patients underwent postoperative radiation alone, whereas 5 patients did not receive any adjunctive treatment. Median follow-up was 29.5 months. No major complications were observed. No patients were found to have residual gross tumor. Disease-free survival was 73.3%, and overall survival was 75.6%. Radical external auditory canal and/or middle ear canal resection is of utmost importance to obtain a good surgical outcome. Postoperative radiotherapy is necessary to obtain good local control; no major adverse effects were observed in the intraoperative radiotherapy patients. The incidence of major complication is minimal after pedicle flap reconstruction.

Original languageEnglish
Pages (from-to)816-821
Number of pages6
JournalJournal of Craniofacial Surgery
Volume20
Issue number3
DOIs
Publication statusPublished - May 2009

Fingerprint

Ear Canal
Middle Ear
Squamous Cell Carcinoma
Temporal Bone
Radiotherapy
Residual Neoplasm
Disease-Free Survival
Retrospective Studies

Keywords

  • External auditory canal
  • Intraoperative radiotherapy (IORT)
  • Petrosectomy
  • Temporal bone squamous cell carcinoma

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery

Cite this

Treatment and outcome of advanced external auditory canal and middle ear squamous cell carcinoma. / Cristalli, Giovanni; Manciocco, Valentina; Pichi, Barbara; Marucci, Laura; Arcangeli, Giorgio; Telera, Stefano; Spriano, Giuseppe.

In: Journal of Craniofacial Surgery, Vol. 20, No. 3, 05.2009, p. 816-821.

Research output: Contribution to journalArticle

Cristalli, Giovanni ; Manciocco, Valentina ; Pichi, Barbara ; Marucci, Laura ; Arcangeli, Giorgio ; Telera, Stefano ; Spriano, Giuseppe. / Treatment and outcome of advanced external auditory canal and middle ear squamous cell carcinoma. In: Journal of Craniofacial Surgery. 2009 ; Vol. 20, No. 3. pp. 816-821.
@article{e154c1d042bc42399afca71e092e9b8e,
title = "Treatment and outcome of advanced external auditory canal and middle ear squamous cell carcinoma",
abstract = "This is a retrospective study to evaluate the outcomes and complications of combined treatment, surgery with or without adjunctive intraoperative radiotherapy, of locally advanced temporal bone squamous cell carcinoma. A series of 17 patients with locally advanced squamous cell carcinoma of the temporal bone were treated between September 2002 and February 2007. Eleven patients had primary tumors, and 6 patients had recurrences. According to the University of Pittsburgh staging system, 5 patients were stage II (T2 N0), 6 patients were stage III (5, T3 N0 and 1, T1 N1), and 6 patients were stage IV (5, T3 N2b and 1, T4 N0). All patients underwent lateral temporal bone resection and pedicle flap reconstruction. Eight patients received intraoperative and postoperative radiotherapies, 4 patients underwent postoperative radiation alone, whereas 5 patients did not receive any adjunctive treatment. Median follow-up was 29.5 months. No major complications were observed. No patients were found to have residual gross tumor. Disease-free survival was 73.3{\%}, and overall survival was 75.6{\%}. Radical external auditory canal and/or middle ear canal resection is of utmost importance to obtain a good surgical outcome. Postoperative radiotherapy is necessary to obtain good local control; no major adverse effects were observed in the intraoperative radiotherapy patients. The incidence of major complication is minimal after pedicle flap reconstruction.",
keywords = "External auditory canal, Intraoperative radiotherapy (IORT), Petrosectomy, Temporal bone squamous cell carcinoma",
author = "Giovanni Cristalli and Valentina Manciocco and Barbara Pichi and Laura Marucci and Giorgio Arcangeli and Stefano Telera and Giuseppe Spriano",
year = "2009",
month = "5",
doi = "10.1097/SCS.0b013e3181a14b99",
language = "English",
volume = "20",
pages = "816--821",
journal = "Journal of Craniofacial Surgery",
issn = "1049-2275",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Treatment and outcome of advanced external auditory canal and middle ear squamous cell carcinoma

AU - Cristalli, Giovanni

AU - Manciocco, Valentina

AU - Pichi, Barbara

AU - Marucci, Laura

AU - Arcangeli, Giorgio

AU - Telera, Stefano

AU - Spriano, Giuseppe

PY - 2009/5

Y1 - 2009/5

N2 - This is a retrospective study to evaluate the outcomes and complications of combined treatment, surgery with or without adjunctive intraoperative radiotherapy, of locally advanced temporal bone squamous cell carcinoma. A series of 17 patients with locally advanced squamous cell carcinoma of the temporal bone were treated between September 2002 and February 2007. Eleven patients had primary tumors, and 6 patients had recurrences. According to the University of Pittsburgh staging system, 5 patients were stage II (T2 N0), 6 patients were stage III (5, T3 N0 and 1, T1 N1), and 6 patients were stage IV (5, T3 N2b and 1, T4 N0). All patients underwent lateral temporal bone resection and pedicle flap reconstruction. Eight patients received intraoperative and postoperative radiotherapies, 4 patients underwent postoperative radiation alone, whereas 5 patients did not receive any adjunctive treatment. Median follow-up was 29.5 months. No major complications were observed. No patients were found to have residual gross tumor. Disease-free survival was 73.3%, and overall survival was 75.6%. Radical external auditory canal and/or middle ear canal resection is of utmost importance to obtain a good surgical outcome. Postoperative radiotherapy is necessary to obtain good local control; no major adverse effects were observed in the intraoperative radiotherapy patients. The incidence of major complication is minimal after pedicle flap reconstruction.

AB - This is a retrospective study to evaluate the outcomes and complications of combined treatment, surgery with or without adjunctive intraoperative radiotherapy, of locally advanced temporal bone squamous cell carcinoma. A series of 17 patients with locally advanced squamous cell carcinoma of the temporal bone were treated between September 2002 and February 2007. Eleven patients had primary tumors, and 6 patients had recurrences. According to the University of Pittsburgh staging system, 5 patients were stage II (T2 N0), 6 patients were stage III (5, T3 N0 and 1, T1 N1), and 6 patients were stage IV (5, T3 N2b and 1, T4 N0). All patients underwent lateral temporal bone resection and pedicle flap reconstruction. Eight patients received intraoperative and postoperative radiotherapies, 4 patients underwent postoperative radiation alone, whereas 5 patients did not receive any adjunctive treatment. Median follow-up was 29.5 months. No major complications were observed. No patients were found to have residual gross tumor. Disease-free survival was 73.3%, and overall survival was 75.6%. Radical external auditory canal and/or middle ear canal resection is of utmost importance to obtain a good surgical outcome. Postoperative radiotherapy is necessary to obtain good local control; no major adverse effects were observed in the intraoperative radiotherapy patients. The incidence of major complication is minimal after pedicle flap reconstruction.

KW - External auditory canal

KW - Intraoperative radiotherapy (IORT)

KW - Petrosectomy

KW - Temporal bone squamous cell carcinoma

UR - http://www.scopus.com/inward/record.url?scp=68249136832&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68249136832&partnerID=8YFLogxK

U2 - 10.1097/SCS.0b013e3181a14b99

DO - 10.1097/SCS.0b013e3181a14b99

M3 - Article

C2 - 19381105

AN - SCOPUS:68249136832

VL - 20

SP - 816

EP - 821

JO - Journal of Craniofacial Surgery

JF - Journal of Craniofacial Surgery

SN - 1049-2275

IS - 3

ER -