TY - JOUR
T1 - Treatment and prognostic factors of papillary thyroid microcarcinoma
AU - Giordano, D.
AU - Gradoni, P.
AU - Oretti, G.
AU - Molina, E.
AU - Ferri, T.
PY - 2010/4
Y1 - 2010/4
N2 - Objective: To discuss the prognostic factors and outcomes of treatment in patients diagnosed with papillary thyroid microcarcinoma. Design: Retrospective observational case review. Setting: Department of Otorhinolaryngology of the tertiary referral teaching hospital of Parma. Participants: Ninety-seven patients diagnosed with PTMC and surgically treated between January 1998 and December 2007. Main outcome measures: Clinical and histopathological characteristics of the study group were identified and statistically analysed. Results: No cancer-related deaths were registered. Incidence of recurrent disease was 9% after a 43 month mean follow-up (range 12-120). Univariate analysis detected that metastases in neck lymph nodes at diagnosis (p = 0.025), a tumour >5 mm in size (p = 0.011), the presence of bilateral tumoural foci (p = 0.007), the presence of capsular invasion (p = 0.001), and the presence of vascular invasion (p = 0.004) were related to recurrent disease. On multivariate analysis, the presence of bilateral tumoural foci (p = 0.030), and the presence of capsular invasion (p = 0.005) were significantly related to tumour recurrence. Conclusion: The prognosis for patients with papillary thyroid microcarcinoma in this series was excellent, with a 100% survival rate and minimal surgical-related morbidity. Nevertheless, approximately 10% of patients developed recurrent disease; aggressive treatment may be justified depending on the presence or absence of prognostic risk factors.
AB - Objective: To discuss the prognostic factors and outcomes of treatment in patients diagnosed with papillary thyroid microcarcinoma. Design: Retrospective observational case review. Setting: Department of Otorhinolaryngology of the tertiary referral teaching hospital of Parma. Participants: Ninety-seven patients diagnosed with PTMC and surgically treated between January 1998 and December 2007. Main outcome measures: Clinical and histopathological characteristics of the study group were identified and statistically analysed. Results: No cancer-related deaths were registered. Incidence of recurrent disease was 9% after a 43 month mean follow-up (range 12-120). Univariate analysis detected that metastases in neck lymph nodes at diagnosis (p = 0.025), a tumour >5 mm in size (p = 0.011), the presence of bilateral tumoural foci (p = 0.007), the presence of capsular invasion (p = 0.001), and the presence of vascular invasion (p = 0.004) were related to recurrent disease. On multivariate analysis, the presence of bilateral tumoural foci (p = 0.030), and the presence of capsular invasion (p = 0.005) were significantly related to tumour recurrence. Conclusion: The prognosis for patients with papillary thyroid microcarcinoma in this series was excellent, with a 100% survival rate and minimal surgical-related morbidity. Nevertheless, approximately 10% of patients developed recurrent disease; aggressive treatment may be justified depending on the presence or absence of prognostic risk factors.
UR - http://www.scopus.com/inward/record.url?scp=77950876977&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77950876977&partnerID=8YFLogxK
U2 - 10.1111/j.1749-4486.2010.02085.x
DO - 10.1111/j.1749-4486.2010.02085.x
M3 - Article
C2 - 20500581
AN - SCOPUS:77950876977
VL - 35
SP - 118
EP - 124
JO - Clinical Otolaryngology
JF - Clinical Otolaryngology
SN - 1749-4478
IS - 2
ER -