Abstract
Liver transplantation (LT) which is currently an established therapy for sma1l, early stage hepatocellular carcinoma (HCC) in patients with cirrhosis requires in most cases long waiting period. Tumor development during the waiting period may be associated with vascular invasion which is a strong factor of postoperative recurrence. Therefore, local treatment of the tumor including trans-arterial chemoembolization (TACE), percutaneous radiofrequency (RF) or partial liver resection can be used before transplantation. In the present paper we reviewed the efficacy of these treatments prior to LT. Although, TACE induced complete tumor necrosis in some patients there is no convincing arguments showing that this treatment reduces the rate of drop out before LT, nor improves the survival after LT. Although, RF can induce complete necrosis in the majority of small tumors (
| Original language | English |
|---|---|
| Pages (from-to) | 993-1000 |
| Number of pages | 8 |
| Journal | Annals of Surgical Oncology |
| Volume | 15 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2008 |
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Keywords
- Downstaging
- Dropout
- Hepatocellular carcinoma
- Radiofrequency ablation
- Resection
- Transarterial chemoembolization
- Transplantation
ASJC Scopus subject areas
- Surgery
- Oncology
Cite this
Treatment before liver transplantation for HCC. / Belghiti, J.; Carr, B. I.; Greig, P. D.; Lencioni, R.; Poon, R. T.
In: Annals of Surgical Oncology, Vol. 15, No. 4, 04.2008, p. 993-1000.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Treatment before liver transplantation for HCC
AU - Belghiti, J.
AU - Carr, B. I.
AU - Greig, P. D.
AU - Lencioni, R.
AU - Poon, R. T.
PY - 2008/4
Y1 - 2008/4
N2 - Liver transplantation (LT) which is currently an established therapy for sma1l, early stage hepatocellular carcinoma (HCC) in patients with cirrhosis requires in most cases long waiting period. Tumor development during the waiting period may be associated with vascular invasion which is a strong factor of postoperative recurrence. Therefore, local treatment of the tumor including trans-arterial chemoembolization (TACE), percutaneous radiofrequency (RF) or partial liver resection can be used before transplantation. In the present paper we reviewed the efficacy of these treatments prior to LT. Although, TACE induced complete tumor necrosis in some patients there is no convincing arguments showing that this treatment reduces the rate of drop out before LT, nor improves the survival after LT. Although, RF can induce complete necrosis in the majority of small tumors (
AB - Liver transplantation (LT) which is currently an established therapy for sma1l, early stage hepatocellular carcinoma (HCC) in patients with cirrhosis requires in most cases long waiting period. Tumor development during the waiting period may be associated with vascular invasion which is a strong factor of postoperative recurrence. Therefore, local treatment of the tumor including trans-arterial chemoembolization (TACE), percutaneous radiofrequency (RF) or partial liver resection can be used before transplantation. In the present paper we reviewed the efficacy of these treatments prior to LT. Although, TACE induced complete tumor necrosis in some patients there is no convincing arguments showing that this treatment reduces the rate of drop out before LT, nor improves the survival after LT. Although, RF can induce complete necrosis in the majority of small tumors (
KW - Downstaging
KW - Dropout
KW - Hepatocellular carcinoma
KW - Radiofrequency ablation
KW - Resection
KW - Transarterial chemoembolization
KW - Transplantation
UR - http://www.scopus.com/inward/record.url?scp=40549118488&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=40549118488&partnerID=8YFLogxK
U2 - 10.1245/s10434-007-9787-8
DO - 10.1245/s10434-007-9787-8
M3 - Article
C2 - 18236111
AN - SCOPUS:40549118488
VL - 15
SP - 993
EP - 1000
JO - Annals of Surgical Oncology
JF - Annals of Surgical Oncology
SN - 1068-9265
IS - 4
ER -