Treatment before liver transplantation for HCC

J. Belghiti, B. I. Carr, P. D. Greig, R. Lencioni, R. T. Poon

Research output: Contribution to journalArticlepeer-review

Abstract

Liver transplantation (LT) which is currently an established therapy for sma1l, early stage hepatocellular carcinoma (HCC) in patients with cirrhosis requires in most cases long waiting period. Tumor development during the waiting period may be associated with vascular invasion which is a strong factor of postoperative recurrence. Therefore, local treatment of the tumor including trans-arterial chemoembolization (TACE), percutaneous radiofrequency (RF) or partial liver resection can be used before transplantation. In the present paper we reviewed the efficacy of these treatments prior to LT. Although, TACE induced complete tumor necrosis in some patients there is no convincing arguments showing that this treatment reduces the rate of drop out before LT, nor improves the survival after LT. Although, RF can induce complete necrosis in the majority of small tumors (

Original languageEnglish
Pages (from-to)993-1000
Number of pages8
JournalAnnals of Surgical Oncology
Volume15
Issue number4
DOIs
Publication statusPublished - Apr 2008

Keywords

  • Downstaging
  • Dropout
  • Hepatocellular carcinoma
  • Radiofrequency ablation
  • Resection
  • Transarterial chemoembolization
  • Transplantation

ASJC Scopus subject areas

  • Surgery
  • Oncology

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