Treatment complications and long-term outcomes of total body irradiation in patients with acute lymphoblastic leukemia: A single institute experience

Francesca De Felice, Lavinia Grapulin, Daniela Musio, Jenny Pomponi, Cinzia Di Felice, Anna Paola Iori, Alice Bertaina, Vincenzo Tombolini

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The aim of this study was to evaluate treatment-related toxicity and clinical outcomes of total body irradiation (TBI) in patients with acute lymphoblastic leukemia (ALL). Patients and Methods: We performed a retrospective review of all patients with ALL who underwent TBI-based conditioning regimen at our Institution between 2000 and 2012. Results: A total of 211 patients were included. The median follow-up was 40 months. The 5-year overall survival and disease-free survival were 64.7% and 62.8%, respectively. The 5-year overall survival rate for the 163 children was 67.6% (95% confidence interval=55-77%). Disease status at time of transplant did not improve disease-free survival. Gastrointestinal acute toxicity was the most common early side-effect (19.9%). Acute graft-versus-host disease was reported in 31 patients (14.7%). Main late toxicities were cataract induction (12.8%) and growth, gonadal and endocrine effects (36%). Conclusion: TBI-based conditioning regimen led to a high survival rate with remarkably low radiation-related toxicity, suggesting that TBI provides a feasible therapeutic option in patients with ALL.

Original languageEnglish
Pages (from-to)4859-4864
Number of pages6
JournalAnticancer Research
Volume36
Issue number9
DOIs
Publication statusPublished - Sep 1 2016

Keywords

  • Acute lymphoblastic leukaemia
  • Child
  • Conditioning regimen
  • Hematologic cancer
  • Radiotherapy
  • Total body irradiation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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