Treatment factors affecting outcomes in HIV-associated non-Hodgkin lymphomas: A pooled analysis of 1546 patients

Stefan K. Barta; Xiaonan Xue; Dan Wang; Roni Tamari; Jeannette Y. Lee; Nicolas Mounier; Lawrence D. Kaplan; Josep Maria Ribera; Michele Spina; Umberto Tirelli; Rudolf Weiss; Lionel Galicier; Francois Boue; Wyndham H. Wilson; Christoph Wyen; Albert Oriol; José Tomás Navarro; Kieron Dunleavy; Richard F. Little; Lee Ratner; Olga Garcia; Mireia Morgades; Scot C. Remick; Ariela Noy; Joseph A. Sparano

doi:10.1182/blood-2013-04-498964

Treatment factors affecting outcomes in HIV-associated non-Hodgkin lymphomas: A pooled analysis of 1546 patients

Stefan K. Barta, Xiaonan Xue, Dan Wang, Roni Tamari, Jeannette Y. Lee, Nicolas Mounier, Lawrence D. Kaplan, Josep Maria Ribera, Michele Spina, Umberto Tirelli, Rudolf Weiss, Lionel Galicier, Francois Boue, Wyndham H. Wilson, Christoph Wyen, Albert Oriol, José Tomás Navarro, Kieron Dunleavy, Richard F. Little, Lee RatnerOlga Garcia, Mireia Morgades, Scot C. Remick, Ariela Noy, Joseph A. Sparano

Centro di Riferimento Oncologico

Research output: Contribution to journal › Article › peer-review

Abstract

Limited comparative data exist for the treatment of HIV-associated non-Hodgkin lymphoma. We analyzed pooled individual patient data for 1546 patients from 19 prospective clinical trials to assess treatment-specific factors (type of chemotherapy, rituximab, and concurrent combination antiretroviral [cART] use) and their influence on the outcomes complete response (CR), progression free survival (PFS), and overall survival (OS). In our analysis, rituximab was associated with a higher CR rate (odds ratio [OR] 2.89; P

Original language	English
Pages (from-to)	3251-3262
Number of pages	12
Journal	Blood
Volume	122
Issue number	19
DOIs	https://doi.org/10.1182/blood-2013-04-498964
Publication status	Published - Nov 7 2013

ASJC Scopus subject areas

Hematology
Biochemistry
Cell Biology
Immunology

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Barta, S. K., Xue, X., Wang, D., Tamari, R., Lee, J. Y., Mounier, N., Kaplan, L. D., Ribera, J. M., Spina, M., Tirelli, U., Weiss, R., Galicier, L., Boue, F., Wilson, W. H., Wyen, C., Oriol, A., Navarro, J. T., Dunleavy, K., Little, R. F., ... Sparano, J. A. (2013). Treatment factors affecting outcomes in HIV-associated non-Hodgkin lymphomas: A pooled analysis of 1546 patients. Blood, 122(19), 3251-3262. https://doi.org/10.1182/blood-2013-04-498964

Treatment factors affecting outcomes in HIV-associated non-Hodgkin lymphomas : A pooled analysis of 1546 patients. / Barta, Stefan K.; Xue, Xiaonan; Wang, Dan; Tamari, Roni; Lee, Jeannette Y.; Mounier, Nicolas; Kaplan, Lawrence D.; Ribera, Josep Maria; Spina, Michele; Tirelli, Umberto; Weiss, Rudolf; Galicier, Lionel; Boue, Francois; Wilson, Wyndham H.; Wyen, Christoph; Oriol, Albert; Navarro, José Tomás; Dunleavy, Kieron; Little, Richard F.; Ratner, Lee; Garcia, Olga; Morgades, Mireia; Remick, Scot C.; Noy, Ariela; Sparano, Joseph A.

In: Blood, Vol. 122, No. 19, 07.11.2013, p. 3251-3262.

Research output: Contribution to journal › Article › peer-review

Barta, SK, Xue, X, Wang, D, Tamari, R, Lee, JY, Mounier, N, Kaplan, LD, Ribera, JM, Spina, M, Tirelli, U, Weiss, R, Galicier, L, Boue, F, Wilson, WH, Wyen, C, Oriol, A, Navarro, JT, Dunleavy, K, Little, RF, Ratner, L, Garcia, O, Morgades, M, Remick, SC, Noy, A & Sparano, JA 2013, 'Treatment factors affecting outcomes in HIV-associated non-Hodgkin lymphomas: A pooled analysis of 1546 patients', Blood, vol. 122, no. 19, pp. 3251-3262. https://doi.org/10.1182/blood-2013-04-498964

Barta, Stefan K. ; Xue, Xiaonan ; Wang, Dan ; Tamari, Roni ; Lee, Jeannette Y. ; Mounier, Nicolas ; Kaplan, Lawrence D. ; Ribera, Josep Maria ; Spina, Michele ; Tirelli, Umberto ; Weiss, Rudolf ; Galicier, Lionel ; Boue, Francois ; Wilson, Wyndham H. ; Wyen, Christoph ; Oriol, Albert ; Navarro, José Tomás ; Dunleavy, Kieron ; Little, Richard F. ; Ratner, Lee ; Garcia, Olga ; Morgades, Mireia ; Remick, Scot C. ; Noy, Ariela ; Sparano, Joseph A. / Treatment factors affecting outcomes in HIV-associated non-Hodgkin lymphomas : A pooled analysis of 1546 patients. In: Blood. 2013 ; Vol. 122, No. 19. pp. 3251-3262.

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abstract = "Limited comparative data exist for the treatment of HIV-associated non-Hodgkin lymphoma. We analyzed pooled individual patient data for 1546 patients from 19 prospective clinical trials to assess treatment-specific factors (type of chemotherapy, rituximab, and concurrent combination antiretroviral [cART] use) and their influence on the outcomes complete response (CR), progression free survival (PFS), and overall survival (OS). In our analysis, rituximab was associated with a higher CR rate (odds ratio [OR] 2.89; P ",

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AU - Tamari, Roni

AU - Lee, Jeannette Y.

AU - Mounier, Nicolas

AU - Kaplan, Lawrence D.

AU - Ribera, Josep Maria

AU - Spina, Michele

AU - Tirelli, Umberto

AU - Weiss, Rudolf

AU - Galicier, Lionel

AU - Boue, Francois

AU - Wilson, Wyndham H.

AU - Wyen, Christoph

AU - Oriol, Albert

AU - Navarro, José Tomás

AU - Dunleavy, Kieron

AU - Little, Richard F.

AU - Ratner, Lee

AU - Garcia, Olga

AU - Morgades, Mireia

AU - Remick, Scot C.

AU - Noy, Ariela

AU - Sparano, Joseph A.

PY - 2013/11/7

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Treatment factors affecting outcomes in HIV-associated non-Hodgkin lymphomas: A pooled analysis of 1546 patients

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