Treatment for T3 to T4a laryngeal cancer by open partial horizontal laryngectomies: Prognostic impact of different pathologic tumor subcategories

Giovanni Succo, Erika Crosetti, Andy Bertolin, Cesare Piazza, Gabriele Molteni, Stefano Cirillo, Massimo Petracchini, Martina Tascone, Andrea Elio Sprio, Giovanni Nicolao Berta, Giorgio Peretti, Livio Presutti, Giuseppe Rizzotto

Research output: Contribution to journalArticle

Abstract

Background: The purpose of this retrospective study was to identify subcategories in cT3 to cT4a supraglottic/glottic cancers, describing their different spreading patterns, and local and locoregional recurrence modes. Methods: Four hundred eighty-nine patients who underwent open partial horizontal laryngectomies (OPHLs) were retrospectively classified as: subcategory I (anterior pT3 with normal arytenoid mobility); subcategory II (posterior pT3 with impaired/absent mobility); subcategory III (anterior pT4 with normal mobility); and subcategory IV (posterior pT4 with impaired/absent mobility). Results: Five-year overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), locoregional, local control, freedom from laryngectomy, and laryngectomy-free survival were significantly better in anterior tumors (subcategories I and III) when compared with the corresponding posterior ones (subcategories II and IV). Conclusion: Anterior cT3 tumors are manageable by OPHL, and this approach could also be proposed in the treatment of early anterior cT4aN0. Despite promising results, OPHLs should be considered under investigation in posterior cT3 tumors due to clinical and biological behavior similar to cT4a tumors.

Original languageEnglish
Pages (from-to)1897-1908
Number of pages12
JournalHead and Neck
Volume40
Issue number9
DOIs
Publication statusPublished - Sep 1 2018

Keywords

  • open partial horizontal laryngectomy
  • supracricoid partial laryngectomy
  • supratracheal partial laryngectomy
  • T3 laryngeal cancer
  • T4 laryngeal cancer

ASJC Scopus subject areas

  • Otorhinolaryngology

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  • Cite this

    Succo, G., Crosetti, E., Bertolin, A., Piazza, C., Molteni, G., Cirillo, S., Petracchini, M., Tascone, M., Sprio, A. E., Berta, G. N., Peretti, G., Presutti, L., & Rizzotto, G. (2018). Treatment for T3 to T4a laryngeal cancer by open partial horizontal laryngectomies: Prognostic impact of different pathologic tumor subcategories. Head and Neck, 40(9), 1897-1908. https://doi.org/10.1002/hed.25176