Treatment of a delayed graft failure after allogeneic bone marrow transplantation with IL-3 and GM-CSF

A. M. Vannucchi, A. Bosi, D. Laszlo, S. Guidi, R. Saccardi, P. Rossi-Ferrini

Research output: Contribution to journalArticle

Abstract

We report on the partial effectiveness of sequential IL-3 and GM-CSF administration, following an ineffective 5-day trial with G-CSF, in a case of delayed graft failure after allogeneic bone marrow transplantation. Therapy with these growth factors was followed by a prompt (within 2 days) increase of neutrophil count, suggesting the possibility of a priming effect due to the previous G-CSF administration. The potential usefulness of this growth factor schedule administration in the treatment of graft failures after allogeneic bone marrow transplantation requires confirmation in controlled trials.

Original languageEnglish
Pages (from-to)341-343
Number of pages3
JournalHaematologica
Volume80
Issue number4
Publication statusPublished - 1995

Keywords

  • bone marrow transplantation
  • GM-CSF
  • graft failure
  • IL-3

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Treatment of a delayed graft failure after allogeneic bone marrow transplantation with IL-3 and GM-CSF'. Together they form a unique fingerprint.

  • Cite this

    Vannucchi, A. M., Bosi, A., Laszlo, D., Guidi, S., Saccardi, R., & Rossi-Ferrini, P. (1995). Treatment of a delayed graft failure after allogeneic bone marrow transplantation with IL-3 and GM-CSF. Haematologica, 80(4), 341-343.