Treatment of a delayed graft failure after allogeneic bone marrow transplantation with IL-3 and GM-CSF

A. M. Vannucchi, A. Bosi, D. Laszlo, S. Guidi, R. Saccardi, P. Rossi-Ferrini

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We report on the partial effectiveness of sequential IL-3 and GM-CSF administration, following an ineffective 5-day trial with G-CSF, in a case of delayed graft failure after allogeneic bone marrow transplantation. Therapy with these growth factors was followed by a prompt (within 2 days) increase of neutrophil count, suggesting the possibility of a priming effect due to the previous G-CSF administration. The potential usefulness of this growth factor schedule administration in the treatment of graft failures after allogeneic bone marrow transplantation requires confirmation in controlled trials.

Original languageEnglish
Pages (from-to)341-343
Number of pages3
JournalHaematologica
Volume80
Issue number4
Publication statusPublished - 1995

Fingerprint

Interleukin-3
Homologous Transplantation
Granulocyte Colony-Stimulating Factor
Granulocyte-Macrophage Colony-Stimulating Factor
Bone Marrow Transplantation
Intercellular Signaling Peptides and Proteins
Transplants
Treatment Failure
Appointments and Schedules
Neutrophils
Therapeutics

Keywords

  • bone marrow transplantation
  • GM-CSF
  • graft failure
  • IL-3

ASJC Scopus subject areas

  • Hematology

Cite this

Vannucchi, A. M., Bosi, A., Laszlo, D., Guidi, S., Saccardi, R., & Rossi-Ferrini, P. (1995). Treatment of a delayed graft failure after allogeneic bone marrow transplantation with IL-3 and GM-CSF. Haematologica, 80(4), 341-343.

Treatment of a delayed graft failure after allogeneic bone marrow transplantation with IL-3 and GM-CSF. / Vannucchi, A. M.; Bosi, A.; Laszlo, D.; Guidi, S.; Saccardi, R.; Rossi-Ferrini, P.

In: Haematologica, Vol. 80, No. 4, 1995, p. 341-343.

Research output: Contribution to journalArticle

Vannucchi, AM, Bosi, A, Laszlo, D, Guidi, S, Saccardi, R & Rossi-Ferrini, P 1995, 'Treatment of a delayed graft failure after allogeneic bone marrow transplantation with IL-3 and GM-CSF', Haematologica, vol. 80, no. 4, pp. 341-343.
Vannucchi, A. M. ; Bosi, A. ; Laszlo, D. ; Guidi, S. ; Saccardi, R. ; Rossi-Ferrini, P. / Treatment of a delayed graft failure after allogeneic bone marrow transplantation with IL-3 and GM-CSF. In: Haematologica. 1995 ; Vol. 80, No. 4. pp. 341-343.
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