Treatment of acquired severe aplastic anemia: Bone marrow transplantation compared with immunosuppressive therapy - The European Group for blood and marrow transplantation experience

Andrea Bacigalupo, Ronald Brand, Rosi Oneto, Barbara Bruno, Gerard Socié, Jakob Passweg, Anna Locasciulli, Maria Teresa Van Lint, André Tichelli, Shaun McCann, Judith Marsh, Per Ljungman, Jill Hows, Pedro Marin, Hubert Schrezenmeier

Research output: Contribution to journalArticlepeer-review

Abstract

Patients with severe aplastic anemia (SAA) can be successfully treated with bone marrow transplantation (BMT) or immunosuppressive therapy (IS). The current outcome using both forms of therapy among 3,669 patients treated in Europe between 1976 and 1998 is reviewed. Significant progress has been made and the overall risk of failure is now low, with survival rates greater than 80% for both treatments. Chronic graft-versus-host disease (GvHD) remains a problem for BMT patients, and carries a high risk of lethal complications. On the other hand, IS patients are exposed to late failure due to relapse or clonal/malignant diseases. First-line BMT from identical siblings is compared with IS therapy in an intent-to-treat analysis of 1,765 patients, regardless of subsequent transplant status. The outcome of SAA patients has improved considerably over time and is influenced by patient variables such as severity of the disease and age, but also by the choice of the Initial treatment. Copyright (C) 2000 by W.B. Saunders Company.

Original languageEnglish
Pages (from-to)69-80
Number of pages12
JournalSeminars in Hematology
Volume37
Issue number1
Publication statusPublished - Jan 2000

ASJC Scopus subject areas

  • Hematology

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