Treatment of advanced breast cancer with a metronomic schedule of oral vinorelbine: what is the opinion of Italian oncologists?

Marina E. Cazzaniga, Elisabetta Munzone, Emilia Montagna, Giovanni Pappagallo

Research output: Contribution to journalArticlepeer-review


Background: The aim of this study was to record the opinions of Italian oncologists about the use of oral vinorelbine administered metronomically in patients with advanced breast cancer. Methods: A series of meetings were held throughout Italy, and participants were asked how much they agreed with each of the several statements. Results: The majority of oncologists agreed that the concept of the minimum biologically effective dose should be used for drugs administered metronomically. Over 50% agreed that metronomic vinorelbine is an option in first-line chemotherapy for patients with advanced breast cancer, including those with a terminal illness and the elderly, as well as in young and fit patients. Just over one-third of experts agreed that a combination of two chemotherapy agents instead of one is not desirable in metastatic breast cancer because of increased toxicity. Most experts agreed that the main aim of a first-line therapy is to control the disease over time and to preserve quality of life. Conclusion: Metronomically administered oral vinorelbine, either as monotherapy or in combination with other drugs, is effective in the long-term treatment of patients with advanced breast cancer. The clinical profiles of patients should be carefully considered to determine the appropriate treatment strategy.

Original languageEnglish
Pages (from-to)805-814
Number of pages10
JournalExpert Review of Anticancer Therapy
Issue number8
Publication statusPublished - Aug 3 2018


  • Advanced breast cancer
  • antiangiogenesis
  • immunomodulation
  • metronomic chemotherapy
  • vinorelbine

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)


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