Treatment of advanced mycosis fungoides by allogeneic stem-cell transplantation with a nonmyeloablative regimen

D. Soligo, A. Ibatici, E. Berti, P. Morandi, P. Longhi, L. Venegoni, M. Corbellino, C. Annaloro, L. Robbiolo, A. Della Volpe, E. Alessi, G. Lambertenghi Deliliers

Research output: Contribution to journalArticlepeer-review

Abstract

Given the poor prognosis of patients with advanced cutaneous T-cell lymphoma and the high transplant-related mortality associated with conventional allogeneic bone marrow transplantation, we performed nonmyeloablative transplantation of allogeneic stem cells (ASCT) from HLA-identical siblings in three patients with this disease. All patients achieved full donor engraftment, clearance of clonal T cells leading to durable complete remissions but experienced high incidence of infections, which proved fatal in one case. These results suggest that nonmyeloablative ASCT is a novel and potentially curative therapy for patients with advanced T-cell lymphomas who have a histocompatible sibling.

Original languageEnglish
Pages (from-to)663-666
Number of pages4
JournalBone Marrow Transplantation
Volume31
Issue number8
DOIs
Publication statusPublished - Apr 2003

Keywords

  • Allogeneic stem cell transplantation
  • Mycosis fungoides
  • Nonmyeloablative regimen

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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