TY - JOUR
T1 - Treatment of advanced mycosis fungoides by allogeneic stem-cell transplantation with a nonmyeloablative regimen
AU - Soligo, D.
AU - Ibatici, A.
AU - Berti, E.
AU - Morandi, P.
AU - Longhi, P.
AU - Venegoni, L.
AU - Corbellino, M.
AU - Annaloro, C.
AU - Robbiolo, L.
AU - Della Volpe, A.
AU - Alessi, E.
AU - Lambertenghi Deliliers, G.
PY - 2003/4
Y1 - 2003/4
N2 - Given the poor prognosis of patients with advanced cutaneous T-cell lymphoma and the high transplant-related mortality associated with conventional allogeneic bone marrow transplantation, we performed nonmyeloablative transplantation of allogeneic stem cells (ASCT) from HLA-identical siblings in three patients with this disease. All patients achieved full donor engraftment, clearance of clonal T cells leading to durable complete remissions but experienced high incidence of infections, which proved fatal in one case. These results suggest that nonmyeloablative ASCT is a novel and potentially curative therapy for patients with advanced T-cell lymphomas who have a histocompatible sibling.
AB - Given the poor prognosis of patients with advanced cutaneous T-cell lymphoma and the high transplant-related mortality associated with conventional allogeneic bone marrow transplantation, we performed nonmyeloablative transplantation of allogeneic stem cells (ASCT) from HLA-identical siblings in three patients with this disease. All patients achieved full donor engraftment, clearance of clonal T cells leading to durable complete remissions but experienced high incidence of infections, which proved fatal in one case. These results suggest that nonmyeloablative ASCT is a novel and potentially curative therapy for patients with advanced T-cell lymphomas who have a histocompatible sibling.
KW - Allogeneic stem cell transplantation
KW - Mycosis fungoides
KW - Nonmyeloablative regimen
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U2 - 10.1038/sj.bmt.1703872
DO - 10.1038/sj.bmt.1703872
M3 - Article
C2 - 12692606
AN - SCOPUS:0037688157
VL - 31
SP - 663
EP - 666
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
SN - 0268-3369
IS - 8
ER -