Treatment of advanced mycosis fungoides by allogeneic stem-cell transplantation with a nonmyeloablative regimen

D. Soligo; A. Ibatici; E. Berti; P. Morandi; P. Longhi; L. Venegoni; M. Corbellino; C. Annaloro; L. Robbiolo; A. Della Volpe; E. Alessi; G. Lambertenghi Deliliers

doi:10.1038/sj.bmt.1703872

Treatment of advanced mycosis fungoides by allogeneic stem-cell transplantation with a nonmyeloablative regimen

D. Soligo, A. Ibatici, E. Berti, P. Morandi, P. Longhi, L. Venegoni, M. Corbellino, C. Annaloro, L. Robbiolo, A. Della Volpe, E. Alessi, G. Lambertenghi Deliliers

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

Given the poor prognosis of patients with advanced cutaneous T-cell lymphoma and the high transplant-related mortality associated with conventional allogeneic bone marrow transplantation, we performed nonmyeloablative transplantation of allogeneic stem cells (ASCT) from HLA-identical siblings in three patients with this disease. All patients achieved full donor engraftment, clearance of clonal T cells leading to durable complete remissions but experienced high incidence of infections, which proved fatal in one case. These results suggest that nonmyeloablative ASCT is a novel and potentially curative therapy for patients with advanced T-cell lymphomas who have a histocompatible sibling.

Original language	English
Pages (from-to)	663-666
Number of pages	4
Journal	Bone Marrow Transplantation
Volume	31
Issue number	8
DOIs	https://doi.org/10.1038/sj.bmt.1703872
Publication status	Published - Apr 2003

Keywords

Allogeneic stem cell transplantation
Mycosis fungoides
Nonmyeloablative regimen

ASJC Scopus subject areas

Hematology
Transplantation

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Soligo, D., Ibatici, A., Berti, E., Morandi, P., Longhi, P., Venegoni, L., Corbellino, M., Annaloro, C., Robbiolo, L., Della Volpe, A., Alessi, E., & Lambertenghi Deliliers, G. (2003). Treatment of advanced mycosis fungoides by allogeneic stem-cell transplantation with a nonmyeloablative regimen. Bone Marrow Transplantation, 31(8), 663-666. https://doi.org/10.1038/sj.bmt.1703872

Treatment of advanced mycosis fungoides by allogeneic stem-cell transplantation with a nonmyeloablative regimen. / Soligo, D.; Ibatici, A.; Berti, E.; Morandi, P.; Longhi, P.; Venegoni, L.; Corbellino, M.; Annaloro, C.; Robbiolo, L.; Della Volpe, A.; Alessi, E.; Lambertenghi Deliliers, G.

In: Bone Marrow Transplantation, Vol. 31, No. 8, 04.2003, p. 663-666.

Research output: Contribution to journal › Article › peer-review

Soligo, D, Ibatici, A, Berti, E, Morandi, P, Longhi, P, Venegoni, L, Corbellino, M, Annaloro, C, Robbiolo, L, Della Volpe, A, Alessi, E & Lambertenghi Deliliers, G 2003, 'Treatment of advanced mycosis fungoides by allogeneic stem-cell transplantation with a nonmyeloablative regimen', Bone Marrow Transplantation, vol. 31, no. 8, pp. 663-666. https://doi.org/10.1038/sj.bmt.1703872

Soligo, D. ; Ibatici, A. ; Berti, E. ; Morandi, P. ; Longhi, P. ; Venegoni, L. ; Corbellino, M. ; Annaloro, C. ; Robbiolo, L. ; Della Volpe, A. ; Alessi, E. ; Lambertenghi Deliliers, G. / Treatment of advanced mycosis fungoides by allogeneic stem-cell transplantation with a nonmyeloablative regimen. In: Bone Marrow Transplantation. 2003 ; Vol. 31, No. 8. pp. 663-666.

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abstract = "Given the poor prognosis of patients with advanced cutaneous T-cell lymphoma and the high transplant-related mortality associated with conventional allogeneic bone marrow transplantation, we performed nonmyeloablative transplantation of allogeneic stem cells (ASCT) from HLA-identical siblings in three patients with this disease. All patients achieved full donor engraftment, clearance of clonal T cells leading to durable complete remissions but experienced high incidence of infections, which proved fatal in one case. These results suggest that nonmyeloablative ASCT is a novel and potentially curative therapy for patients with advanced T-cell lymphomas who have a histocompatible sibling.",

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