Treatment of atrial fibrillation with a dual defibrillator in heart failure patients (TRADE HF): Protocol for a randomized clinical trial

Giovanni L. Botto, Giuseppe Boriani, Stefano Favale, Maurizio Landolina, Giulio Molon, Claudio Tondo, Mauro Biffi, Giuseppe Grandinetti, Paolo De Filippo, Giovanni Raciti, Luigi Padeletti

Research output: Contribution to journalArticle

Abstract

Background: Heart failure(HF) and atrial fibrillation(AF) frequently coexist in the same patient and are associated with increased mortality and frequent hospitalizations. As the concomitance of AF and HF is often associated with a poor prognosis, the prompt treatment of AF in HF patients may significantly improve outcome.Methods/design: Recent implantable cardiac resynchronization (CRT) devices allow electrical therapies to treat AF automatically. TRADE-HF (trial registration: NCT00345592; http://www.clinicaltrials.gov) is a prospective, randomized, double arm study aimed at demonstrating the efficacy of an automatic, device-based therapy for treatment of atrial tachycardia and fibrillation(AT/AF) in patients indicated for CRT. The study compares automatic electrical therapy to a traditional more usual treatment of AT/AF: the goal is to demonstrate a reduction in a combined endpoint of unplanned hospitalizations for cardiac reasons, death from cardiovascular causes or permanent AF when using automatic atrial therapy as compared to the traditional approach involving hospitalization for symptoms and in-hospital treatment of AT/AF.Discussion: CRT pacemaker with the additional ability to convert AF as well as ventricular arrhythmias may play a simultaneous role in rhythm control and HF treatment. The value of the systematic implantation of CRT ICDs with the capacity to deliver atrial therapy in HF patients at risk of AF has not yet been explored. The TRADE-HF study will assess in CRT patients whether a strategy based on automatic management of atrial arrhythmias might be a valuable option to reduce the number of hospital admission and to reduce the progression the arrhythmia to a permanent form.Trial registration: NCT00345592.

Original languageEnglish
Article number44
JournalTrials
Volume12
DOIs
Publication statusPublished - Feb 15 2011

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Treatment of atrial fibrillation with a dual defibrillator in heart failure patients (TRADE HF): Protocol for a randomized clinical trial'. Together they form a unique fingerprint.

  • Cite this

    Botto, G. L., Boriani, G., Favale, S., Landolina, M., Molon, G., Tondo, C., Biffi, M., Grandinetti, G., De Filippo, P., Raciti, G., & Padeletti, L. (2011). Treatment of atrial fibrillation with a dual defibrillator in heart failure patients (TRADE HF): Protocol for a randomized clinical trial. Trials, 12, [44]. https://doi.org/10.1186/1745-6215-12-44